Escape from Isoantiserum Inhibition of Lymphocyte-mediated Cytotoxicity

Overview

Journal J Exp Med

Specialties Allergy & Immunology
General Medicine

Date 1973 Jan 1

PMID 4734590

Citations 4

Authors

R B Faanes

Y S Choi

R A GOOD

Affiliations

Soon will be listed here.

Abstract

Isoantiserum (IS) inhibition of lymphocyte-mediated cytotoxicity (LMC) was studied using an in vitro (51)Cr release assay system. In the early phase of incubation, LMC was competitively inhibited by IS. However, as the incubation continued, LMC irreversibly overcame IS inhibition (the "escape" phenomenon). Addition of fresh antiserum did not alter the course of the escape. Low-temperature incubation of isoantibody-coated target cells delayed the onset of the escape. We have excluded the possibility that the escape phenomenon is induced by complement or by LMC mediated by antigen-antibody complex. It is hypothesized that antibody directed toward an actively metabolizing target cell induces an alteration in the cell membrane that alters further interaction with the antibody. However, sensitivity to lymphocyte cytotoxicity is maintained.

Citing Articles

Isoantiserum-augmented development of lymphocyte-mediated cytotoxicity.

Faanes R, Walker M, Choi Y J Exp Med. 1976; 144(5):1284-93.

PMID: 1086884 PMC: 2190458. DOI: 10.1084/jem.144.5.1284.

Participation of the H-2 antigens of tumor cells in their lysis by syngeneic T cells.

Schrader J, Edelman G J Exp Med. 1976; 143(3):601-14.

PMID: 1082492 PMC: 2190130. DOI: 10.1084/jem.143.3.601.

Responses of an experimental solid tumour to irradiation: A comparison of modes of fractionation.

Schenken L, Poulakos L, Hagemann R Br J Cancer. 1975; 31(2):228-36.

PMID: 809050 PMC: 2009365. DOI: 10.1038/bjc.1975.29.

Levamisole augments the cytotoxic T-cell response depending on the dose of drugs and antigen administered.

Faanes R, Dillon P, Choi Y Clin Exp Immunol. 1977; 27(3):502-6.

PMID: 405166 PMC: 1540944.

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