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Antibody-dependent Lymphoid Cell-mediated Cytotoxicity: No Requirement for Thymus-derived Lymphocytes

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Journal Science
Specialty Science
Date 1972 Jan 14
PMID 5008439
Citations 53
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Abstract

The capacity of lymphoid cells from nonsensitized mice to lyse antibody-coated target erythrocytes in vitro does not require the presence of thymus-derived or thymus-dependent lymphocytes. Thus, spleen cells from thymus-deprived mice and spleen cell populations from which thymus-dependent lymphocytes had been removed were fully competent to mediate destruction of antibody-coated target cells. However, prior treatment of spleen cell populations with antibody to kappa chains diminished this function, suggesting a role for bone marrow-derived lymphocytes.

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