Cellular Requirements for the Primary in Vitro Antibody Response to DNP-ficoll

Overview

Journal J Exp Med

Specialties Allergy & Immunology
General Medicine

Date 1974 May 1

PMID 4596514

Citations 28

Authors

D E Mosier

B M Johnson

W E Paul

P R MCMASTER

Affiliations

Soon will be listed here.

Abstract

The cellular requirements for the primary in vitro IgM and IgG response to dinitrophenyl-substituted Ficoll were examined. Neither thymus-derived lymphocytes nor macrophage-rich splenic adherent cells were required for anti-DNP antibody synthesis. DNP-Ficoll is therefore tentatively classified as a "thymic-independent" antigen.

Citing Articles

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B-lymphocyte responses to trinitrophenyl-conjugated Ficoll: requirement for T lymphocytes and Ia-bearing adherent cells.

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Dissociation of the anti-hapten and anti-carrier responses of mice injected with dinitrophenylated lipopolysaccharide.

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