Differential Tolerance of Thymus-independent and Thymus-dependent Antibody Responses

Overview

Journal Immunology

Specialty Allergy & Immunology

Date 1978 Feb 1

PMID 342401

Citations 7

Authors

J P Tite

S Marshall-Clarke

J H Playfair

Affiliations

Soon will be listed here.

Abstract

The effect of pre-immunization with soluble haptenated serum proteins or haptenated carbohydrates on the subsequent responses to the hapten in thymus-dependent or thymus-independent form was investigated. In certain cases both thymus-dependent and -independent responses were suppressed whilst in others a differential suppression of thymus-independent responsiveness was observed. These results are discussed in terms of B-cell subpopulations and mechanisms of tolerance induction.

Citing Articles

Immunoregulatory effects of covalent antigen-antibody complexes. III. Enhancement or suppression depending on the time of administration of complex relative to a T-independent antigen.

Tite J, Morrison C, Taylor R Immunology. 1981; 42(2):355-62.

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The expression of surface IgD on B cells responsive to thymus-independent and thymus-dependent antigens and its requirement for B-cell triggering.

Marshall-Clarke S, Keeler K, Parkhouse M Immunology. 1983; 48(2):393-400.

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Definition of conditions that enable antigen-specific activation of the majority of isolated trinitrophenol-binding B cells.

Cambier J, Monroe J, Neale M J Exp Med. 1982; 156(6):1635-49.

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Cyclosporin A has differential effects on the responses of murine B cells to TI antigens and B-cell mitogens.

Higham A, Sells R, Marshall-Clarke S Immunology. 1986; 59(2):203-7.

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Time-dependence and selectivity of immunosuppressive agents.

BERENBAUM M Immunology. 1979; 36(2):355-65.

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