Reversal Learning Enhanced by Lysergic Acid Diethylamide (LSD): Concomitant Rise in Brain 5-hydroxytryptamine Levels

Overview

Journal Br J Pharmacol

Publisher Wiley

Specialty Pharmacology

Date 1974 Nov 1

PMID 4458849

Citations 11

Authors

A R King

I L Martin

K A Melville

Affiliations

Soon will be listed here.

Abstract

1 Small doses of lysergic acid diethylamide (LSD) (12.5-50 mug/kg) consistently facilitated learning of a brightness discrimination reversal.2 2-Bromo-lysergic acid diethylamide (BOL-148), a structural analogue of LSD, with similar peripheral anti-5-hydroxytrypamine activity but no psychotomimetic properties, had no effect in this learning situation at a similar dose (25 mug/kg).3 LSD, but not BOL-148, caused a small but significant increase in brain 5-hydroxytryptamine levels, but had no effect on the levels of catecholamines in the brain at 25 mug/kg.

Citing Articles

Psychedelics for the Treatment of Obsessive-Compulsive Disorder: Efficacy and Proposed Mechanisms.

Collins H Int J Neuropsychopharmacol. 2024; 27(12).

PMID: 39611453 PMC: 11635828. DOI: 10.1093/ijnp/pyae057.

Lasting dynamic effects of the psychedelic 2,5-dimethoxy-4-iodoamphetamine ((±)-DOI) on cognitive flexibility.

Sabanovic M, Lazari A, Blanco-Pozo M, Tisca C, Tachrount M, Martins-Bach A Mol Psychiatry. 2024; 29(6):1810-1823.

PMID: 38321122 PMC: 11371652. DOI: 10.1038/s41380-024-02439-2.

Synthetic surprise as the foundation of the psychedelic experience.

De Filippo R, Schmitz D Neurosci Biobehav Rev. 2024; 157:105538.

PMID: 38220035 PMC: 10839673. DOI: 10.1016/j.neubiorev.2024.105538.

Can psychedelics enhance group psychotherapy? A discussion on the therapeutic factors.

Ponomarenko P, Seragnoli F, Calder A, Oehen P, Hasler G J Psychopharmacol. 2023; 37(7):660-678.

PMID: 36855289 PMC: 10350738. DOI: 10.1177/02698811231155117.

Pivotal mental states.

Brouwer A, Carhart-Harris R J Psychopharmacol. 2020; 35(4):319-352.

PMID: 33174492 PMC: 8054165. DOI: 10.1177/0269881120959637.

References

Boakes R, Bradley P, Briggs I, Dray A . Antagonism of 5-hydroxytryptamine by LSD 25 in the central nervous system: a possible neuronal basis for the actions of LSD 25. Br J Pharmacol. 1970; 40(2):202-18. PMC: 1702892. DOI: 10.1111/j.1476-5381.1970.tb09914.x. View

Bradley P, Key B . The effect of drugs on arousal responses produced by electrical stimulation of the reticular formation of the brain. Electroencephalogr Clin Neurophysiol. 1958; 10(1):97-110. DOI: 10.1016/0013-4694(58)90107-x. View

Bradley P, Elkes J . The effects of some drugs on the electrical activity of the brain. Brain. 1957; 80(1):77-117. DOI: 10.1093/brain/80.1.77. View

Bignami G . Facilitation of avoidance acquisition by LSD-25. Possible effects on drive modulating systems. Psychopharmacologia. 1972; 25(2):146-51. DOI: 10.1007/BF00423191. View

Key B . The effect of drugs on discrimination and sensory generalisation of auditory stimuli in cats. Psychopharmacologia. 1961; 2:352-63. DOI: 10.1007/BF00404123. View

Key B . Alterations in the generalisation of visual stimuli induced by lysergic acid diethylamide in cats. Psychopharmacologia. 1964; 6(5):327-37. DOI: 10.1007/BF00404243. View

ROSECRANS J, Lovell R, Freedman D . Effects of lysergic acid diethylamide on the metabolism of brain 5-hydroxytryptamine. Biochem Pharmacol. 1967; 16(10):2011-21. DOI: 10.1016/0006-2952(67)90313-9. View

Sparber S, Tilson H . Environmental influences upon drug-induced suppression of operant behavior. J Pharmacol Exp Ther. 1971; 179(1):1-9. View

Himwich H, ALPERS H . Psychopharmacology. Annu Rev Pharmacol. 1970; 10:313-34. DOI: 10.1146/annurev.pa.10.040170.001525. View

10.

Martin I, Ansell G . A sensitive gas chromatographic procedure for the estimation of noradrenaline, dopamine and 5-hydroxytryptamine in rat brain. Biochem Pharmacol. 1973; 22(4):521-33. DOI: 10.1016/0006-2952(73)90295-5. View

11.

Leonard B, Tonge S . The effects of some hallucinogenic drugs upon the metabolism of noradrenaline. Life Sci. 1969; 8(15):815-25. DOI: 10.1016/0024-3205(69)90142-8. View

12.

Brawley P, DUFFIELD J . The pharmacology of hallucinogens. Pharmacol Rev. 1972; 24(1):31-66. View

13.

Key B . The effect of LSD-25 on the interaction between conditioned and non-conditioned stimuli in a simple avoidance situation. Psychopharmacologia. 1964; 6(5):319-26. DOI: 10.1007/BF00404242. View

14.

ANDEN N, CORRODI H, Fuxe K, Hokfelt T . Evidence for a central 5-hydroxytryptamine receptor stimulation by lysergic acid diethylamide. Br J Pharmacol. 1968; 34(1):1-7. PMC: 1703426. DOI: 10.1111/j.1476-5381.1968.tb07943.x. View

15.

Freedman D . Effects of LSD-25 on brain serotonin. J Pharmacol Exp Ther. 1961; 134:160-6. View

16.

SCHECHTER M, Winter J . Effect of BOL on the LSD-induced alteration of flicker discrimination in the rat. Arch Int Pharmacodyn Ther. 1972; 196(1):64-9. View

17.

Diaz J, Huttunen M . Persistent increase in brain serotonin turnover after chronic administration of LSD in the rat. Science. 1971; 174(4004):62-4. DOI: 10.1126/science.174.4004.62. View

18.

Freedman D . The psychopharmacology of hallucinogenic agents. Annu Rev Med. 1969; 20:409-18. DOI: 10.1146/annurev.me.20.020169.002205. View

19.

KENDLER H, Lachman R . Habit reversal as a function of schedule of reinforcement and drive strength. J Exp Psychol. 1958; 55(6):584-91. DOI: 10.1037/h0044114. View

20.

Appel J, Freedman D . CHEMICALLY-INDUCED ALTERATIONS IN THE BEHAVIORAL EFFECTS OF LSD-25. Biochem Pharmacol. 1964; 13:861-9. DOI: 10.1016/0006-2952(64)90030-9. View