Persistent Increase in Brain Serotonin Turnover After Chronic Administration of LSD in the Rat

Overview

Journal Science

Specialty Science

Date 1971 Oct 1

PMID 5120868

Citations 4

Authors

J L Diaz

M O Huttunen

Affiliations

Soon will be listed here.

Abstract

Lysergic acid diethylamide at doses of 20 micrograms per kilogram per day was administered orally to rats for I month. Eighteen hours after the final dose a 25 to 30 percent increase in the synthesis and turnover of serotonin was noted, as well as a moderate but significant increase in the concentration of tryptophan (18 percent) and serotonin (13 percent) in the brain.

Citing Articles

Reversal learning enhanced by lysergic acid diethylamide (LSD): concomitant rise in brain 5-hydroxytryptamine levels.

King A, Martin I, Melville K Br J Pharmacol. 1974; 52(3):419-26.

PMID: 4458849 PMC: 1777004. DOI: 10.1111/j.1476-5381.1974.tb08611.x.

Effect of LSD-25 and 1-methyl-d-lysergic acid butanolamide on rat brain and platelet serotonin levels.

Torre M, Bogetto F, Torre E Psychopharmacologia. 1974; 36(2):117-22.

PMID: 4407808 DOI: 10.1007/BF00421783.

Effects of single and multiple dose LSD on endogenous levels of brain tyrosine and catecholamines.

Smith R, Boggan W, Freedman D Psychopharmacologia. 1975; 42(3):271-6.

PMID: 1161985 DOI: 10.1007/BF00421267.

The relation between cerebral serotonin levels and conditioned behaviour in the rat following the administration of LSD-25 and UML.

Torre M, Torre E, Bogetto F Psychopharmacologia. 1975; 41(3):245-7.

PMID: 1153613 DOI: 10.1007/BF00428931.