Characterization of the Coronary Vascular -adrenoceptor in the Pig

Overview

Journal Br J Pharmacol

Publisher Wiley

Specialty Pharmacology

Date 1972 Oct 1

PMID 4405612

Citations 7

Authors

G M Drew

G P Levy

Affiliations

Soon will be listed here.

Abstract

The beta-adrenoceptor in pig coronary vascular smooth muscle has been characterized by the use of a selective agonist, salbutamol and a selective antagonist, practolol. In coronary artery strips contracted with KCI, salbutamol had only marginal relaxant activity and was a partial agonist compared with isoprenaline. Practolol had relatively high antagonist potency against isoprenaline (pA(2) 6.59). It is concluded that the pig coronary vascular,beta-adrenoceptor is of the beta(1)-type.

Citing Articles

The beta-adrenoceptor of pig coronary arteries: determination of beta 1 and beta 2 subtypes by radioligand binding.

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In vitro activity of RO363, a beta1-adrenoceptor selective agonist.

Iakovidis D, Malta E, McPherson G, RAPER C Br J Pharmacol. 1980; 68(4):677-85.

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Effects of single doses of alprenolol and two cardioselective beta-blockers (H 87-07 and H 93-26) on exercise-induced angina pectoris.

Adolfsson L, ARESKOG N, Furberg C, Johnsson G Eur J Clin Pharmacol. 1974; 7(2):111-8.

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The release of a coronary vasodilator metabolite from the guinea-pig isolated perfused heart stimulated by catecholamines, histamine and electrical pacing and by exposure to anoxia.

Broadley K Br J Pharmacol. 1976; 58(1):89-100.

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Effects of uptake inhibitors on responses of sheep coronary arteries to catecholamines and sympathetic nerve stimulation.

Brine F, CORNISH E, Miller R Br J Pharmacol. 1979; 67(4):553-61.

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