Radioimmunoassay for Avian C-type Virus Group-specific Antigen: Detection in Normal and Virus-transformed Cells

Overview

Journal J Virol

Publisher American Society for Microbiology

Date 1973 Jun 1

PMID 4351459

Citations 17

Authors

J R Stephenson

R E WILSNACK

S A Aaronson

Affiliations

Soon will be listed here.

Abstract

A radioimmunoassay has been developed for detection of avian C-type virus (30,000 mol wt) group-specific (gs) antigen. The method is 10- to 1,000-fold more sensitive than immunological methods previously available. By the radioimmunoassay technique, normal chicken embryo cells, which have previously been classified as gs negative or weakly gs positive, contain clearly detectable amounts of gs antigen. The assay has been used to study the effect of chemical induction and superinfection by mammalian C-type viruses on the expression of avian gs antigen in mammalian cells nonproductively transformed by avian sarcoma viruses.

Citing Articles

Detection of a protein of avian leukoviruses in uninfected chick cells by radioimmunoassay.

Chen J, Hanafusa H J Virol. 1974; 13(2):340-6.

PMID: 16789140 PMC: 355302. DOI: 10.1128/JVI.13.2.340-346.1974.

Expression of endogenous avian myeloblastosis virus information in different chicken cells.

Chen J J Virol. 1980; 36(1):162-70.

PMID: 6255203 PMC: 353627. DOI: 10.1128/JVI.36.1.162-170.1980.

Major structural proteins of type B, type C, and type D oncoviruses share interspecies antigenic determinants.

Barbacid M, Long L, Aaronson S Proc Natl Acad Sci U S A. 1980; 77(1):72-6.

PMID: 6153801 PMC: 348210. DOI: 10.1073/pnas.77.1.72.

Modified radioimmunoassay for murine sarcoma-leukemia virus group-specific antigen.

Spira G, Biswal N, Dreesman G Appl Microbiol. 1974; 28(2):239-44.

PMID: 4368924 PMC: 186693. DOI: 10.1128/am.28.2.239-244.1974.

Radioimmunoassay for the major structural protein of hamster type C viruses.

Charman H, Kim N, Gilden R J Virol. 1974; 14(4):910-7.

PMID: 4138682 PMC: 355598. DOI: 10.1128/JVI.14.4.910-917.1974.

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