Expression of Endogenous RNA C-type Virus Group-specific Antigens in Mammalian Cells

Overview

Journal J Virol

Publisher American Society for Microbiology

Date 1973 Sep 1

PMID 4127032

Citations 25

Authors

J R Stephenson

S A Aaronson

Affiliations

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Abstract

Highly sensitive and specific radioimmunoassays are described for quantitation of the intraspecies determinants of several mammalian C-type viral group-specific (gs) antigens. An interspecies (gs-3) immunoassay has been developed which has both the broad reactivity and great sensitivity necessary for detection of C-type viruses where intraspecies gs assays are not available. By using these immunoassays, the expression of endogenous virus-specified gs antigens in mammalian cells of different species has been studied. Whereas mouse gs antigen was clearly detectable in tissue culture cells of several mouse strains, the respective gs antigens of rat, cat, Chinese hamster, woolly monkey, and gibbon ape were not detectable in cells of those species, using assays of comparable sensitivity. Thus, differences exist in the level of endogenous virus expression in cells of different mammalian species.

Citing Articles

Application of a novel radioimmunoassay to identify baculovirus structural proteins that share interspecies antigenic determinants.

Smith G, Summers M J Virol. 1981; 39(1):125-37.

PMID: 16789210 PMC: 171272. DOI: 10.1128/JVI.39.1.125-137.1981.

Activation of a type C virus particle in cells from the inbred mouse strain 129/J: antigenic relationship with the horizontally transmitted type C viruses of primates. Brief report.

Rapp U, Barbacid M Arch Virol. 1983; 76(4):373-9.

PMID: 6625885 DOI: 10.1007/BF01311205.

Immunological relationships of OMC-1, an endogenous virus of owl monkeys, with mammalian and avian type C viruses.

Barbacid M, Daniel M, Aaronson S J Virol. 1980; 33(1):561-6.

PMID: 6154152 PMC: 288575. DOI: 10.1128/JVI.33.1.561-566.1980.

Major structural proteins of type B, type C, and type D oncoviruses share interspecies antigenic determinants.

Barbacid M, Long L, Aaronson S Proc Natl Acad Sci U S A. 1980; 77(1):72-6.

PMID: 6153801 PMC: 348210. DOI: 10.1073/pnas.77.1.72.

Demonstration of a genetic factor influencing spontaneous release of a xenotropic virus of mouse cells.

Stephenson J, Aaronson S Proc Natl Acad Sci U S A. 1974; 71(12):4925-9.

PMID: 4373736 PMC: 434012. DOI: 10.1073/pnas.71.12.4925.

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