Antibody to the RNA-dependent DNA Polymerase of Mammalian C-type RNA Tumor Viruses

Overview

Journal Proc Natl Acad Sci U S A

Specialty Science

Date 1971 May 1

PMID 4325004

Citations 21

Authors

S A Aaronson

W P Parks

E M Scolnick

G J Todaro

Affiliations

Soon will be listed here.

Abstract

Sera from rats bearing transplantable tumors induced by murine C-type tumor viruses contain an inhibitor of the activity of the viral RNA-dependent DNA polymerase. The inhibitor is shown to be an immunoglobulin (IgG) directed against the enzyme. Antiserum made in rabbits against partially purified murine leukemia virus polymerase also inhibits the polymerases of other mammalian C-type RNA-containing tumor viruses. Thus, the polymerases from different mammalian tumor viruses are antigenically related.

Citing Articles

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Demonstration of a genetic factor influencing spontaneous release of a xenotropic virus of mouse cells.

Stephenson J, Aaronson S Proc Natl Acad Sci U S A. 1974; 71(12):4925-9.

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Oncornavirus expression in human x mouse hybrid cells segregating mouse chromosomes.

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Cellular replication and the persistence of inducible RNA type C viruses.

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Autogenous immunity to endogenous RNA tumor virus. Identification of antibody reactivity to select viral antigens.

Ihle J, Hanna Jr M, Roberson L, Kenney F J Exp Med. 1974; 139(6):1568-81.

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