Common Cell Surface Antigen Associated with Mammalian C-type RNA Viruses. Cell Membrane-bound Gs Antigen

Overview

Journal J Exp Med

Specialties Allergy & Immunology
General Medicine

Date 1974 Apr 1

PMID 4131513

Citations 23

Authors

T Yoshiki

R C MELLORS

W D Hardy Jr

E Fleissner

Affiliations

Soon will be listed here.

Abstract

The indirect membrane immunofluorescence test and the absorption analysis of rabbit anti-FeLV, rabbit anti-FeLVp 30, and rabbit anti-MuLVp 30 antisera yielded the following conclusions. An antigen shared by mammalian (murine and feline) C-type RNA leukemia and sarcoma viruses was detected on the surface of cells infected or transformed by C-type viruses. The antigen was characterized as membrane-bound gs antigen bearing two determinants, membrane-bound gs-1, intraspecies-specific antigenic determinant, and membrane-bound gs-3, interspecies-specific antigenic determinant. Membrane-bound gs antigen was located on the cell surface, frequently near the site of virus budding but not on the envelope of murine C-type RNA virus.

Citing Articles

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Rat lymphoid cell lines with human T cell leukemia virus production. I. Biological and serological characterization.

Tateno M, Kondo N, Itoh T, Chubachi T, Togashi T, Yoshiki T J Exp Med. 1984; 159(4):1105-16.

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Immunohistologic detection of antigen related to primate type C retrovirus p30 in normal human placentas.

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The immunobiology of the feline leukemia virus.

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Induction of tumor-specific cell-mediated immunity by a noninfectious type-C virus.

Datta S, McCormick K, TRENTIN J Infect Immun. 1981; 33(1):126-9.

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