Genetic Control by the Hr-locus of Susceptibility and Resistance to Leukemia

Overview

Journal Proc Natl Acad Sci U S A

Specialty Science

Date 1969 Jul 1

PMID 4310515

Citations 18

Authors

H Meier

D D Myers

R J HUEBNER

Affiliations

Soon will be listed here.

Abstract

Leukemia was observed in 45 per cent of hairless mice at 8 to 10 months of age and 72 per cent at 18 months. The incidence of leukemia in normal heterozygous mice of the same age is about one per cent at 10 months and increases to 20 per cent at 18 months. Other tumors are rare; two mammary adenocarcinomas occurred in heterozygotes, and an epidermal squamous cell carcinoma was found in a hairless mouse. Murine leukemia virus was isolated from normal and leukemic mice of both genotypes on SWR/J- and C57L/J-METC, but not BALB/cJ-METC. If this virus is responsible for the leukemia in HRS/J mice, the mutant gene (hr) enhances susceptibility and the wild-type allele (+) induces resistance to leukemogenesis, i.e., malignant transformation of reticulo-endothelial tissues occurs rather than inhibition of viral replication as both genotypes harbor virus in high titers. The two types of HRS/J mice, hr/hr and hr/+, are congenic, i.e., they differ only with respect to one allele (hr or +) at the mutant locus. This single gene difference should lend itself to analysis of the interaction of a specific gene and murine leukemia virus.

Citing Articles

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Patterns of hairless (hr) gene expression in mouse hair follicle morphogenesis and cycling.

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Expression of leukemogenic recombinant viruses associated with a recessive gene in HRS/J mice.

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References

Hartley J, Rowe W, CAPPS W, HUEBNER R . Complement fixation and tissue culture assays for mouse leukemia viruses. Proc Natl Acad Sci U S A. 1965; 53(5):931-8. PMC: 301351. DOI: 10.1073/pnas.53.5.931. View

Lilly F . The inheritance of susceptibility to the Gross leukemia virus in mice. Genetics. 1966; 53(3):529-39. PMC: 1211037. DOI: 10.1093/genetics/53.3.529. View

Lilly F . The histocompatibility-2 locus and susceptibility to tumor induction. Natl Cancer Inst Monogr. 1966; 22:631-42. View

Fraumeni Jr J, Miller R . Epidemiology of human leukemia: recent observations. J Natl Cancer Inst. 1967; 38(4):593-605. View

Nandi S . The histocompatability-2 locus and susceptibility to bittner virus borne by red blood cells in mice. Proc Natl Acad Sci U S A. 1967; 58(2):485-92. PMC: 335661. DOI: 10.1073/pnas.58.2.485. View

HUEBNER R . The murine leukemia-sarcoma virus complex. Proc Natl Acad Sci U S A. 1967; 58(3):835-42. PMC: 335711. DOI: 10.1073/pnas.58.3.835. View

STEEVES R, Bennett M, MIRAND E, CUDKOWICZ G . Genetic control by the W locus of susceptibility to (Friend) spleen focus-forming virus. Nature. 1968; 218(5139):372-4. DOI: 10.1038/218372a0. View

TENNANT J, Snell G . The H-2 locus and viral leukemogenesis as studied in congenic strains of mice. J Natl Cancer Inst. 1968; 41(2):597-604. View

Bennett M, STEEVES R, CUDKOWICZ G, MIRAND E, Russell L . Mutant Sl alleles of mice affect susceptibility to Friend spleen focus-forming virus. Science. 1968; 162(3853):564-5. DOI: 10.1126/science.162.3853.564. View

10.

Todaro G, Aaronson S . Human cell strains susceptible to focus formation by human adenovirus type 12. Proc Natl Acad Sci U S A. 1968; 61(4):1272-8. PMC: 225251. DOI: 10.1073/pnas.61.4.1272. View

11.

Todaro G . Variable susceptibility of human cell strains to SV40 transformation. Natl Cancer Inst Monogr. 1968; 29:271-5. View

12.

Law L . The flexed-tail-anemia gene (f) and induced leukemia in mice. J Natl Cancer Inst. 1952; 12(5):1119-26. View

13.

HUEBNER R, Rowe W, Turner H, LANE W . SPECIFIC ADENOVIRUS COMPLEMENT-FIXING ANTIGENS IN VIRUS-FREE HAMSTER AND RAT TUMORS. Proc Natl Acad Sci U S A. 1963; 50:379-89. PMC: 221184. DOI: 10.1073/pnas.50.2.379. View

14.

Chieco-Bianchi L, FIORE-DONATI L, DEBENEDICTIS G, Tridente G . INFLUENCE OF URETHANE ON SUSCEPTIBILITY TO LEUKEMIA INDUCTION BY GRAFFI VIRUS IN ADULT MICE. Nature. 1963; 199:292-3. DOI: 10.1038/199292a0. View

15.

Lieberman M, Haran-Ghera N, Kaplan H . POTENTIATION OF VIRUS LEUKAEMOGENESIS IN C57BL MICE BY X-IRRADIATION OR URETHANE. Nature. 1964; 203:420-2. DOI: 10.1038/203420b0. View

16.

Payne L, Biggs P . DIFFERENCES BETWEEN HIGHLY INBRED LINES OF CHICKENS IN THE RESPONSE TO ROUS SARCOMA VIRUS OF THE CHORIOALLANTOIC MEMBRANE AND OF EMBRYONIC CELLS IN TISSUE CULTURE. Virology. 1964; 24:610-6. DOI: 10.1016/0042-6822(64)90215-6. View