Disproportion in T-cell Subpopulations in Immunodeficient Mutant Hr/hr Mice

Overview

Journal J Exp Med

Specialties Allergy & Immunology
General Medicine

Date 1979 Jan 1

PMID 310859

Citations 9

Authors

A B Reske-Kunz

M P Scheid

E A Boyse

Affiliations

Soon will be listed here.

Abstract

Mice of the HRS strain, which carry the mutant gene hr, were examined for abnormalities in representation of the three T-cell sets Ly1, Ly23, and Ly123 in the spleen. The salient feature of hr/hr mice, which are immunologically deficient, in comparison with +/hr segregants, was a gross disproportion in numbers of cells belonging to the Ly1 and Ly123 sets, at the age of 3--3.5 mo. At this age, Ly123 cells of hr/hr spleen outnumbered Ly1 cells by 2:1, whereas in +/hr spleens Ly123 cells were outnumbered by approximately 1:2. Cells from pooled lymph nodes of hr/hr mice did not show a correspondingly gross disporprotion of Ly1 and Ly123 cells. Total counts of splenic T cells, and of B cells, were not significantly different in hr/hr and +/hr mice.

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