Suppression of Murine Type-C RNA Virogenes by Type-specific Oncornavirus Vaccines: Prospects for Prevention of Cancer

Overview

Journal Proc Natl Acad Sci U S A

Specialty Science

Date 1976 Feb 1

PMID 174116

Citations 8

Authors

R J HUEBNER

R V Gilden

W T LANE

R Toni

R W TRIMMER

P R Hill

Affiliations

Soon will be listed here.

Abstract

Immunization of crossbred and F1 mice with combined killed and live Gross leukemia virus AKR type-C viral vaccines suppressed endogeneous N-type AKR virus up to 10,000-fold for significant periods during early life. Since several previous studies in the same and similar crossbred systems revealed direct correlations between low and high levels of type-C virus early in life with low and high incidences of leukemia and other cancers later in life, we believe that prospects for suppression of spontaneous neoplasms are good; however, 8-14 months will be required to achieve the final results. Should cancers be prevented by serotype-specific vaccines, such evidence would provide conclusive proof of endogenous viral etiology.

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