Alpha 2.0
Login Register
» Articles » PMID: 418137

Isolated Hapten-binding Receptors of Sensitized Lymphocytes. III. Evidence for Idiotypic Restriction of T-cell Receptors

Overview
Journal J Exp Med
Specialties Allergy & Immunology
General Medicine
Date 1978 May 1
PMID 418137
Citations 11
Authors
U Krawinkel
M Cramer
I Melchers
K Rajewsky
Affiliations
Soon will be listed here.
Abstract

The primary antibody response of C57BL/6 mice to the 4-hydroxy-3-nitrophenylacetyl (NP) hapten is restricted to antibody molecules expressing the NPb idiotype. This idiotype is a genetic marker for V genes in the heavy chain linkage group. In the secondary response, the frequency of NPb idiotype-positive molecules within the antibody population drops to very low values. Accordingly, isolated NP binding receptors from NP-sensitized B lymphocytes are largely devoid of this idiotype. In contrast, the NPb idiotype is expressed on the majority of the receptor fractions which we consider T-cell derived. This finding suggests that the antigen receptors of T lymphocytes may be restricted to the expression of major (germ-line encoded?) heavy chain idiotypes.

Citing Articles

Chromosome assignment of the tumor-specific antigen of a 3-methylcholanthrene-induced mouse sarcoma.

Pravtcheva D, DeLeo A, Ruddle F, Old L J Exp Med. 1981; 154(3):964-77.

PMID: 7276830 PMC: 2186453. DOI: 10.1084/jem.154.3.964.

Altered lymphocyte recognition repertoire during ageing. III. Changes in MHC restriction patterns in parental T lymphocytes and diminution in T suppressor function.

Gorczynski R, Kennedy M, MacRae S Immunology. 1984; 52(4):611-20.

PMID: 6235179 PMC: 1454669.

Immunoglobulin idiotopes expressed by T cells. I. Expression of distinct idiotopes detected by monoclonal antibodies on antigen-specific suppressor T cells.

cerny J, Heusser C, Wallich R, Hammerling G, Eardley D J Exp Med. 1982; 156(3):719-30.

PMID: 6213731 PMC: 2186786. DOI: 10.1084/jem.156.3.719.

The immune response to virus infections.

Onions D Vet Immunol Immunopathol. 1983; 4(1-2):237-77.

PMID: 6191431 PMC: 7119848. DOI: 10.1016/0165-2427(83)90059-4.

Presence of IgT-C and I-A subregion-encoded determinants on distinct chains of monoclonal antigen-specific augmenting factor derived from a T cell hybridoma.

Nakajima P, Ochi A, Owen F, Tada T J Exp Med. 1983; 157(6):2110-20.

PMID: 6189953 PMC: 2187042. DOI: 10.1084/jem.157.6.2110.

References
1.
Krawinkel U, Cramer M, Jack R, Rajewsky K, Makela O . Isolated hapten-binding receptors of sensitized lymphocytes. I. Receptors from nylon wool-enriched mouse T lymphocytes lack serological markers of immunoglobulin constant domains but express heavy chain variable portions. Eur J Immunol. 1977; 7(8):566-73. DOI: 10.1002/eji.1830070814. View
2.
Makela O, Karjalainen K . Inherited immunoglobulin idiotypes of the mouse. Immunol Rev. 1977; 34:119-38. DOI: 10.1111/j.1600-065x.1977.tb00370.x. View
3.
Rajewsky K, Eichmann K . Antigen receptors of T helper cells. Contemp Top Immunobiol. 1977; 7:69-112. DOI: 10.1007/978-1-4684-3054-7_3. View
4.
Binz H, Wigzell H . Antigen-binding, idiotypic T-lymphocyte receptors. Contemp Top Immunobiol. 1977; 7:113-77. DOI: 10.1007/978-1-4684-3054-7_4. View
5.
Krawinkel U, Cramer M, Berek C, Hammerling G, Black S, Rajewsky K . On the structure of the T-cell receptor for antigen. Cold Spring Harb Symp Quant Biol. 1977; 41 Pt 1:285-94. DOI: 10.1101/sqb.1977.041.01.034. View