Isolated Hapten-binding Receptors of Sensitized Lymphocytes. II. Receptors from Nylon Wool-enriched Rabbit T Lymphocytes Lack Serological Determinants of Immunoglobulin Constant Domains but Carry the A Locus Allotypic Markers

Overview

Journal J Exp Med

Specialties Allergy & Immunology
General Medicine

Date 1977 Sep 1

PMID 408458

Citations 7

Authors

U Krawinkel

M Cramer

R G MAGE

A S KELUS

K Rajewsky

Affiliations

Soon will be listed here.

Abstract

Hapten-binding receptor material was isolated from sensitized rabbit lymphocytes by a method described previously for murine receptor material. The material was separated into a fraction expressing immunoglobulin determinants (anti-Ig+ fraction) and a fraction lacking known class and type-specific determinants of Ig constant domains (anti-Ig- fraction). We present evidence in support of the notion that--in analogy to the mouse system--the anti-Ig+ fraction is B-cell-derived, whereas the anti-Ig- fraction originates from T lymphocytes. Receptors of the anti-Ig- phenotype are found to express a locus allotypic determinants and, thus, appear to carry variable portions of immunoglobulin heavy chains.

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