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Histamine H2-receptors in the Sheep Bronchus and Cat Trachea: the Action of Burimamide

Overview
Journal Br J Pharmacol
Publisher Wiley
Specialty Pharmacology
Date 1973 Jun 1
PMID 4150268
Citations 28
Authors
P Eyre
Affiliations
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Abstract

Histamine-induced relaxation of the sheep bronchus was antagonized by burimamide but not by mepyramine, indicating the presence of H(2)-receptors. Mepyramine or burimamide alone produced partial antagonism of histamine-induced relaxation of the cat trachea. Both inhibitors added simultaneously effectively abolished the histamine response, suggesting that both H(1)- and H(2)-receptors are active in relaxing the cat trachea.

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References
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