The Schultz-Dale Reaction: a Review

Overview

Journal Agents Actions

Specialty Pharmacology

Date 1978 Apr 1

PMID 352112

Citations 21

Authors

N Chand

P Eyre

Affiliations

Soon will be listed here.

Abstract

Vascular (pulmonary and hepatic blood vessels) and nonvascular (gastro-intestinal, reproductive and respiratory systems) smooth muscle preparations obtained from specifically sensitized animals of numerous species including man contract to specific antigen in vitro (Schultz-Dale phenomenon). This immunopharmacological technique is a useful tool to demonstrate immediate-type hypersensitivity in actively or passively sensitized tissues and may be used to investigate the nature of the principal pharmacological mediators involved in a particular tissue as well as to screen anti-anaphylactic (anti-allergic) drugs. However, much remains to be investigated on the complex mechanisms of action of antigen, desensitization and resensitization (recovery) of anaphylactic responsiveness.

Citing Articles

Repeated-Dose Toxicity of Lauric Acid and Its Preventive Effect Against Tracheal Hyper-Responsiveness in Wistar Rats with Possible Molecular Targets.

Figueiredo I, Martins A, Cavalcanti A, Fernandes J, Gomes L, Vieira M Pharmaceuticals (Basel). 2025; 18(2).

PMID: 40006035 PMC: 11859213. DOI: 10.3390/ph18020221.

Anaphylaxis-induced premature uterine contractions: a case report and literature review.

Warintaksa P, Lertrat W, Romero R, Vivithanaporn P, Mongkolsuk P, Kamlungkuea T BMC Pregnancy Childbirth. 2024; 24(1):197.

PMID: 38481196 PMC: 10935842. DOI: 10.1186/s12884-024-06297-2.

New phosphodiesterase-4 inhibitors present airways relaxant activity in a guinea pig acute asthma model.

Martins I, de Melo Medeiros M, Vasconcelos L, Silva M, Queiroga F, Cavalcante-Silva L Naunyn Schmiedebergs Arch Pharmacol. 2023; 397(6):4419-4434.

PMID: 38108836 DOI: 10.1007/s00210-023-02905-8.

Functional and morphologic dysfunctions in the airways of rats submitted to an experimental model of obesity-exacerbated asthma.

Ferreira S, Pessoa R, Figueiredo I, Lima J, de Moura T, Bezerra C Sci Rep. 2022; 12(1):9540.

PMID: 35681069 PMC: 9184493. DOI: 10.1038/s41598-022-13551-0.

Virgin Coconut Oil Supplementation Prevents Airway Hyperreactivity of Guinea Pigs with Chronic Allergic Lung Inflammation by Antioxidant Mechanism.

Vasconcelos L, Silva M, Costa A, de Oliveira G, Souza I, Righetti R Oxid Med Cell Longev. 2020; 2020:5148503.

PMID: 32089769 PMC: 7008286. DOI: 10.1155/2020/5148503.

References

Cirstea M, SUHACIU G . Role of histamine, substance P and slow-reacting substance of anaphylaxis (SRS-A) in the Schultz-Dale reaction of the guinea-pig ileum. Arch Int Physiol Biochim. 1968; 76(2):344-62. DOI: 10.3109/13813456809058711. View

TOLLACKSON K, Frick O . Response of human smooth muscle in Schultz-Dale experiments. J Allergy. 1966; 37(4):195-203. DOI: 10.1016/0021-8707(66)90114-6. View

Mota I . Effect of antigen and octylamine on mast cells and histamine content of sensitized guinea-pig tissues. J Physiol. 1959; 147:425-36. PMC: 1357094. DOI: 10.1113/jphysiol.1959.sp006253. View

Eyre P, Lewis A . Acute systemic anaphylaxis in the horse. Br J Pharmacol. 1973; 48(3):426-37. PMC: 1776115. DOI: 10.1111/j.1476-5381.1973.tb08351.x. View

Fink M, ROTHLAUF M . In vitro anaphylaxis in the sensitized mouse uterus. Proc Soc Exp Biol Med. 1955; 90(2):477-80. DOI: 10.3181/00379727-90-22071. View

DALE H . The mechanism of anaphylaxis. Acta Allergol. 1952; 5(3):191-206. DOI: 10.1111/j.1398-9995.1952.tb03451.x. View

Burka J, Eyre P . Modulation of the formation and release of bovine SRS-A in vitro by several anti-anaphylactic drugs. Int Arch Allergy Appl Immunol. 1975; 49(6):774-81. DOI: 10.1159/000231461. View

Eyre P . The Schultz-Dale reaction in bovine pulmonary smooth muscles. Br J Pharmacol. 1970; 40(1):166P-167P. PMC: 1702657. View

Patterson R, Miyamoto T, Reynolds L, PRUZANSKY J . Comparative studies of two models of allergic respiratory disease. Int Arch Allergy Appl Immunol. 1967; 32(1):31-45. DOI: 10.1159/000229914. View

10.

DWORETZKY M . Role of histamine or other released substances in anaphylaxis in isolated guinea pig ileum. Am J Physiol. 1959; 197(1):31-3. DOI: 10.1152/ajplegacy.1959.197.1.31. View

11.

Alonso-Deflorida F, Del Castillo J, Gonzalez C, Sanchez V . On the pharmacological and anaphylactic responsiveness of denervated skeletal muscle of the guinea-pig. Br J Pharmacol Chemother. 1965; 25(3):610-20. PMC: 1510626. DOI: 10.1111/j.1476-5381.1965.tb01785.x. View

12.

Rose J, FEINBERG A . Histamine antagonists; comparative antianaphylactic activity of some new antihistaminic drugs. J Allergy. 2010; 18(3):149-55. DOI: 10.1016/0021-8707(47)90100-7. View

13.

Okamura T, Shina Y . Inhibitory action of some antihistaminics on the anaphylactic contraction in guinea pig's taenia coli. Jpn J Pharmacol. 1972; 22(5):587-97. DOI: 10.1254/jjp.22.587. View

14.

BINAGHI R, Liacopoulos-Briot M, HALPERN B, Liacopoulos P . Influence of the ionic strength of the medium on the anaphylactic sensitization of isolated tissues in vitro. Nature. 1960; 187:697-8. DOI: 10.1038/187697a0. View

15.

BOREUS L, WESTERHOLM B . 5-Hydroxytryptamine in the Schultz-Dale reaction. Acta Physiol Scand. 1962; 56:17-25. DOI: 10.1111/j.1748-1716.1962.tb02478.x. View

16.

Chand N, Eyre P . Atypical (relaxant) response to histamine in cat bronchus. Agents Actions. 1977; 7(2):183-90. DOI: 10.1007/BF01969970. View

17.

Aitken M, Deline T, Eyre P . Influence of the method of sensitization on some features of anaphylaxis in calves. J Comp Pathol. 1975; 85(3):351-60. DOI: 10.1016/0021-9975(75)90021-3. View

18.

Chand N, Eyre P . The pharmacology of anaphylaxis in the chicken intestine. Br J Pharmacol. 1976; 57(3):399-408. PMC: 1667235. DOI: 10.1111/j.1476-5381.1976.tb07680.x. View

19.

HALPERN B . Experimental research on a new series of chemical substances with powerful antihistaminic activity; the thiodiphenylamine derivatives. J Allergy. 2010; 18(4):263-72. DOI: 10.1016/0021-8707(47)90050-6. View

20.

FEIGEN G, CAMPBELL D . The relative sensitivity of the mucosal and peritoneal surfaces of guinea-pig ileum to histamine, acetylcholine and specific antigens. Am J Physiol. 2010; 145:676-80. DOI: 10.1152/ajplegacy.1946.145.5.676. View