Kinetics and Maintenance of Acquired Resistance in Mice to Listeria Monocytogenes

Overview

Journal Infect Immun

Publisher American Society for Microbiology

Specialty Allergy & Immunology

Date 1977 Jun 1

PMID 408273

Citations 8

Authors

R J Kearns

D J Hinrichs

Affiliations

Soon will be listed here.

Abstract

In the mouse system, acquired resistance to Listeria monocytogenes can only be demonstrated after immunization with viable microorganisms. A successful state of immunity cannot be elicited with formalin-killed organisms or bacterial cell-derived products. Viable, serologically cross-reactive organisms (not mouse pathogenic) do not induce a state of immunity as measured by acquired resistance. The duration of immunity, once established, is dose independent, and the absolute interval of its existence is not extended by secondary challenge with large numbers of viable organisms. The decline of immunity in actively immunized animals is not altered by antigenic challenge with formalin-killed cells or cell products. This indicates that the cellular requirements for the development of host resistance are similar for induction as well as maintenance. In vitro measurements of cellular immunity by migration inhibition indicate that formalin-killed organisms as well as cell products were recognized by actively sensitized lymphocytes obtained from immune animals.

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References

NORTH R . Nature of "memory" in T-cell-mediated antibacterial immunity: anamnestic production of mediator T cells. Infect Immun. 1975; 12(4):754-60. PMC: 415352. DOI: 10.1128/iai.12.4.754-760.1975. View

NORTH R, Deissler J . Nature of "memory" in T-cell mediated antibacterial immunity: cellular parameters that distinguish between the active immune response and a state of "memory". Infect Immun. 1975; 12(4):761-7. PMC: 415353. DOI: 10.1128/iai.12.4.761-767.1975. View

Groves W, Davis Jr F, SELLS B . Spectrophotometric determination of microgram quantities of protein without nucleic acid interference. Anal Biochem. 1968; 22(2):195-210. DOI: 10.1016/0003-2697(68)90307-2. View

Pearson L, OSEBOLD J . Effects of antithymocyte and antimacrophage sera on the survival of mice infected with Listeria monocytogenes. Infect Immun. 1973; 7(3):479-86. PMC: 422704. DOI: 10.1128/iai.7.3.479-486.1973. View

NORTH R . Cellular mediators of anti-Listeria immunity as an enlarged population of short lived, replicating T cells. Kinetics of their production. J Exp Med. 1973; 138(2):342-55. PMC: 2139407. DOI: 10.1084/jem.138.2.342. View

Pearson L, OSEBOLD J . Effects of antithymocyte sera and antimacrophage sera on cell-mediated immune reactions in Listeria-infected mice. Infect Immun. 1974; 9(1):127-33. PMC: 414776. DOI: 10.1128/iai.9.1.127-133.1974. View

OSEBOLD J, Pearson L, Medin N . Relationship of antimicrobial cellular immunity to delayed hypersensitivity in Listeriosis. Infect Immun. 1974; 9(2):354-62. PMC: 414809. DOI: 10.1128/iai.9.2.354-362.1974. View

Petit J, UNANUE E . Effects of bacterial products on lymphocytes and macrophages: their possible role in natural resistance to listeria infetion in mice. J Immunol. 1974; 113(3):984-92. View

Lane F, UNANUE E . Requirement of thymus (T) lymphocytes for resistance to listeriosis. J Exp Med. 1972; 135(5):1104-12. PMC: 2138983. DOI: 10.1084/jem.135.5.1104. View

10.

SIDDIQUE I, Srivastava K . Cell wall and cytoplasmic components of Listeria monocytogenes. Am J Vet Res. 1973; 34(4):567-70. View

11.

Mackaness G . The influence of immunologically committed lymphoid cells on macrophage activity in vivo. J Exp Med. 1969; 129(5):973-92. PMC: 2138649. DOI: 10.1084/jem.129.5.973. View

12.

NORTH R . Cellular kinetics associated with the development of acquired cellular resistance. J Exp Med. 1969; 130(2):299-314. PMC: 2138681. DOI: 10.1084/jem.130.2.299. View

13.

NORTH R . The relative importance of blood monocytes and fixed macrophages to the expression of cell-mediated immunity to infection. J Exp Med. 1970; 132(3):521-34. PMC: 2138809. DOI: 10.1084/jem.132.3.521. View

14.

Miki K, Mackaness G . THE PASSIVE TRANSFER OF ACQUIRED RESISTANCE TO LISTERIA MONOCYTOGENES. J Exp Med. 1964; 120:93-103. PMC: 2137717. DOI: 10.1084/jem.120.1.93. View

15.

David J, AL-ASKARI S, LAWRENCE H, Thomas L . DELAYED HYPERSENSITIVITY IN VITRO. I. THE SPECIFICITY OF INHIBITION OF CELL MIGRATION BY ANTIGENS. J Immunol. 1964; 93:264-73. View

16.

Mackaness G . Cellular resistance to infection. J Exp Med. 1962; 116:381-406. PMC: 2137547. DOI: 10.1084/jem.116.3.381. View

17.

Rodriguez G, McClatchy J, Campbell P . Induction of Resistance by Listeria monocytogenes Cell Wall Fraction. Infect Immun. 1974; 10(5):1163-9. PMC: 423077. DOI: 10.1128/iai.10.5.1163-1169.1974. View