Induction of Resistance by Listeria Monocytogenes Cell Wall Fraction

Overview

Journal Infect Immun

Publisher American Society for Microbiology

Specialty Allergy & Immunology

Date 1974 Nov 1

PMID 16558105

Citations 20

Authors

G E Rodriguez

J K McClatchy

P A Campbell

Affiliations

Soon will be listed here.

Abstract

A crude cell wall fraction of Listeria monocytogenes was prepared by sonic disruption and differential centrifugation of viable, washed cultures. When injected into mice, this sterile, crude cell wall fraction protected mice against an intraperitoneal challenge with 18 to 85 50% mean lethal dose of L. monocytogenes. Resistance was greatly enhanced when bacterial endotoxin (lipopolysaccharide) was injected along with the cell wall fraction. Resistance was measured both by enumerating the bacteria in the livers and spleens of vaccinated and control mice and by survival studies. Two major lines of evidence suggest that the resistance induced by cell wall fraction is at least in part specific. Unlike non-specific resistance, the cell wall fraction-induced resistance was relatively long-lived, (i.e., it was demonstrable 6 weeks after the last injection of cell wall fraction and lipopolysaccharide). In addition, cell wall fraction protected against challenge with L. monocytogenes, but not against challenge with S. typhimurium.

Citing Articles

Immunological properties of Actinomyces viscosus: comparison of blastogenic and adjuvant activities.

Chen P, Farrar J, Genco R Infect Immun. 1980; 28(1):212-9.

PMID: 7189748 PMC: 550914. DOI: 10.1128/iai.28.1.212-219.1980.

Adjuvant activity of purified peptidoglycan of Listeria monocytogenes in mice and guinea pigs.

Saiki I, Kamisango K, Tanio Y, Okumura H, Yamamura Y, Azuma I Infect Immun. 1982; 38(1):58-65.

PMID: 6815094 PMC: 347697. DOI: 10.1128/iai.38.1.58-65.1982.

Prolongation of acquired cellular resistance to Listeria monocytogenes.

Willers J, Hofhuis F, van der Meer C Immunology. 1982; 46(4):787-92.

PMID: 6809603 PMC: 1555466.

Effects of dimethyldioctadecylammonium bromide on phagocytosis and digestion of Listeria monocytogenes by mouse peritoneal macrophages.

Hofhuis F, van der Meer C, Kersten M, Rutten V, Willers J Immunology. 1981; 43(3):425-31.

PMID: 6788683 PMC: 1555040.

Lipoteichoic acid from Listeria monocytogenes.

Hether N, Jackson L J Bacteriol. 1983; 156(2):809-17.

PMID: 6415040 PMC: 217899. DOI: 10.1128/jb.156.2.809-817.1983.

References

Armstrong A, Sword C . CELLULAR RESISTANCE IN LISTERIOSIS. J Infect Dis. 1964; 114:258-64. DOI: 10.1093/infdis/114.3.258. View

Iida T, Tajima M . Stimulation of non-specific resistance by heterologous endotoxins and experimental immunity to Bordetella pertussis in mice. Immunology. 1971; 21(2):313-22. PMC: 1408125. View

Miki K, Mackaness G . THE PASSIVE TRANSFER OF ACQUIRED RESISTANCE TO LISTERIA MONOCYTOGENES. J Exp Med. 1964; 120:93-103. PMC: 2137717. DOI: 10.1084/jem.120.1.93. View

Mackaness G, Blanden R . Cellular immunity. Prog Allergy. 1967; 11:89-140. View

Mackaness G . Resistance to intracellular infection. J Infect Dis. 1971; 123(4):439-45. DOI: 10.1093/infdis/123.4.439. View

Gray M, Killinger A . Listeria monocytogenes and listeric infections. Bacteriol Rev. 1966; 30(2):309-82. PMC: 440999. DOI: 10.1128/br.30.2.309-382.1966. View

Klasky S, Pickett M . Immunogenicity and specificity of Listeria monocytogenes cell walls. J Infect Dis. 1968; 118(1):65-75. DOI: 10.1093/infdis/118.1.65. View

Coppel S, YOUMANS G . Specificity of the anamnestic response produced by Listeria monocytogenes or Mycobacterium tuberculosis to challenge with Listeria monocytogenes. J Bacteriol. 1969; 97(1):127-33. PMC: 249561. DOI: 10.1128/jb.97.1.127-133.1969. View

Mackaness G . The influence of immunologically committed lymphoid cells on macrophage activity in vivo. J Exp Med. 1969; 129(5):973-92. PMC: 2138649. DOI: 10.1084/jem.129.5.973. View

10.

Ruskin J, McIntosh J, Remington J . Studies on the mechanisms of resistance to phylogenetically diverse intracellular organisms. J Immunol. 1969; 103(2):252-9. View

11.

Ruskin J, Remington J . Resistance to intracellular infection in mice immunized with Toxoplasma vaccine and adjuvant. J Reticuloendothel Soc. 1971; 9(5):465-79. View

12.

Alexander P, Evans R . Endotoxin and double stranded RNA render macrophages cytotoxic. Nat New Biol. 1971; 232(29):76-8. DOI: 10.1038/newbio232076a0. View

13.

Bartlema H, Braunius R . Studies on vaccination against Listeria infections. Antonie Van Leeuwenhoek. 1971; 37(2):261-2. DOI: 10.1007/BF02218493. View

14.

Remington J, Merigan T . Synthetic polyanions protect mice against intracellular bacterial infection. Nature. 1970; 226(5243):361-3. DOI: 10.1038/226361a0. View

15.

Rotta J, Prendergast T, KARAKAWA W, Harmon C, Krause R . Enhanced resistance to streptococcal infection induced in mice by cell wall mucopeptide. J Exp Med. 1965; 122(5):877-90. PMC: 2138114. DOI: 10.1084/jem.122.5.877. View

16.

Mackaness G, Blanden R, Collins F . Host-parasite relations in mouse typhoid. J Exp Med. 1966; 124(4):573-83. PMC: 2138243. DOI: 10.1084/jem.124.4.573. View

17.

DUBOS R, Schaedler R . Reversible changes in the susceptibility of mice to bacterial infections. I. Changes brought about by injection of pertussis vaccine or of bacterial endotoxins. J Exp Med. 1956; 104(1):53-65. PMC: 2136634. DOI: 10.1084/jem.104.1.53. View

18.

Rowley D . Rapidly induced changes in the level of non-specific immunity in laboratory animals. Br J Exp Pathol. 1956; 37(3):223-34. PMC: 2082161. View

19.

OSEBOLD J, SAWYER M . Immunization studies on listeriosis in mice. J Immunol. 1957; 78(4):262-8. View

20.

Hasenclever H, KARAKAWA W . Immunization of mice against Listeria monocytogenes. J Bacteriol. 1957; 74(5):584-6. PMC: 289966. DOI: 10.1128/jb.74.5.584-586.1957. View