Replication of Measles Virus in Human Lymphocytes

Overview

Journal J Exp Med

Specialties Allergy & Immunology
General Medicine

Date 1985 Jun 1

PMID 4009115

Citations 22

Authors

T Hyypia

P Korkiamaki

R Vainionpaa

Affiliations

Soon will be listed here.

Abstract

Replication of measles virus was restricted in human peripheral blood mononuclear cells (PBMC). However, in in vitro-infected, unstimulated cells, active synthesis of viral RNA and proteins occurred, while the release of infectious virus could not be detected. Stimulation with PHA caused a productive infection cycle comparable to the lytic infection. Replication of viral RNA was demonstrated in both T and B cells, and in both OKT4+- and OKT8+-depleted T cell subsets. The presence of measles virus RNA was detected in PBMC isolated from measles patients, and the production of the immunoreactive hemagglutinin protein was defective in these cells.

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References

Denhardt D . A membrane-filter technique for the detection of complementary DNA. Biochem Biophys Res Commun. 1966; 23(5):641-6. DOI: 10.1016/0006-291x(66)90447-5. View

Laemmli U . Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature. 1970; 227(5259):680-5. DOI: 10.1038/227680a0. View

Sullivan J, Barry D, Lucas S, Albrecht P . Measles infection of human mononuclear cells. I. Acute infection of peripheral blood lymphocytes and monocytes. J Exp Med. 1975; 142(3):773-84. PMC: 2189913. DOI: 10.1084/jem.142.3.773. View

JOSEPH B, LAMPERT P, Oldstone M . Replication and persistence of measles virus in defined subpopulations of human leukocytes. J Virol. 1975; 16(6):1638-49. PMC: 355773. DOI: 10.1128/JVI.16.6.1638-1649.1975. View

Arstila P, Vuorimaa T, Kalimo K, Halonen P, Viljanen M, Granfors K . A solid-phase radioimmunoassay for IgG and IgM antibodies against measles virus. J Gen Virol. 1977; 34(1):167-76. DOI: 10.1099/0022-1317-34-1-167. View

Laurila P, Virtanen I, WARTIOVAARA J, Stenman S . Fluorescent antibodies and lectins stain intracellular structures in fixed cells treated with nonionic detergent. J Histochem Cytochem. 1978; 26(4):251-7. DOI: 10.1177/26.4.207770. View

Joffe M, Rabson A . Dissociation of lymphokine production and blastogenesis in children with measles infections. Clin Immunol Immunopathol. 1978; 10(3):335-43. DOI: 10.1016/0090-1229(78)90190-3. View

Lucas C, Rezee A, Galama J . Activation of measles virus from silently infected human lymphocytes. J Exp Med. 1978; 148(4):940-52. PMC: 2185014. DOI: 10.1084/jem.148.4.940. View

Vainiopaa R, Ziola B, Salmi A . Measles virus polypeptides in purified virions and in infected cells. Acta Pathol Microbiol Scand B. 1978; 86B(6):379-85. DOI: 10.1111/j.1699-0463.1978.tb00060.x. View

10.

Towbin H, Staehelin T, Gordon J . Electrophoretic transfer of proteins from polyacrylamide gels to nitrocellulose sheets: procedure and some applications. Proc Natl Acad Sci U S A. 1979; 76(9):4350-4. PMC: 411572. DOI: 10.1073/pnas.76.9.4350. View

11.

Wrzos H, Kulczycki J, Laskowski Z, Matacz D, BRZOSKO W . Detection of measles virus antigen(s) in peripheral lymphocytes from patients with subacute sclerosing panencephalitis. Arch Virol. 1979; 60(3-4):291-7. DOI: 10.1007/BF01317500. View

12.

Huddlestone J, LAMPERT P, Oldstone M . Virus-lymphocyte interactions: infection of Tg and Tm subsets by measles virus. Clin Immunol Immunopathol. 1980; 15(3):502-9. DOI: 10.1016/0090-1229(80)90062-8. View

13.

Arneborn P, Biberfeld G . T-lymphocyte subpopulations in relation to immunosuppression in measles and varicella. Infect Immun. 1983; 39(1):29-37. PMC: 347903. DOI: 10.1128/iai.39.1.29-37.1983. View

14.

Jacobson S, McFarland H . Measles virus persistence in human lymphocytes: a role for virus-induced interferon. J Gen Virol. 1982; 63(2):351-7. DOI: 10.1099/0022-1317-63-2-351. View

15.

Arneborn P, Biberfeld G, Forsgren M, von Stedingk L . Specific and non-specific B cell activation in measles and varicella. Clin Exp Immunol. 1983; 51(1):165-72. PMC: 1536744. View

16.

Eskola J, Nurmi T, Ruuskanen O . Defective B cell function associated with inherited interstitial deletion of the short arm of the X chromosome. J Immunol. 1983; 131(3):1218-21. View

17.

Sternberg J, Jeppesen P . Dot-blotting--a novel screening assay for antibodies in hybridoma cultures. J Immunol Methods. 1983; 64(1-2):39-43. DOI: 10.1016/0022-1759(83)90382-4. View

18.

Hyypia T, Eskola J, Laine M, Meurman O . B-cell function in vitro during rubella infection. Infect Immun. 1984; 43(2):589-92. PMC: 264339. DOI: 10.1128/iai.43.2.589-592.1984. View

19.

Rose J, Bellini W, McFarlin D, McFarland H . Human cellular immune response to measles virus polypeptides. J Virol. 1984; 49(3):988-91. PMC: 255562. DOI: 10.1128/JVI.49.3.988-991.1984. View

20.

Casali P, Rice G, Oldstone M . Viruses disrupt functions of human lymphocytes. Effects of measles virus and influenza virus on lymphocyte-mediated killing and antibody production. J Exp Med. 1984; 159(5):1322-37. PMC: 2187306. DOI: 10.1084/jem.159.5.1322. View