A Bird's Eye View to the Homeostatic, Alzheimer and Glioblastoma Attractors

Overview

Journal Heliyon

Specialty Social Sciences

Date 2025 Mar 3

PMID 40028606

Authors

Joan Nieves

Gabriel Gil

Augusto Gonzalez

Affiliations

Soon will be listed here.

Abstract

Dimensional reduction analysis of available data for white matter of the brain allows to locate the normal (homeostatic), Glioblastoma and Alzheimer's disease attractors in gene expression space and to identify paths related to transitions like carcinogenesis or Alzheimer's disease onset. A predefined path for aging is also apparent, which is consistent with the hypothesis of programmatic aging. In addition, reasonable assumptions about the relative strengths of attractors allow to draw a schematic landscape of fitness: a Wright's diagram. These simple diagrams reproduce known relations between aging, Glioblastoma and Alzheimer's disease, and rise interesting questions like the possible connection between programmatic aging and Glioblastoma in this tissue. We anticipate that similar multiple diagrams in other tissues could be useful in the understanding of the biology of apparently unrelated diseases or disorders, and in the discovery of unexpected clues for their treatment.

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