Extracellular Vesicles Loaded MiRNAs As Potential Modulators Shared Between Glioblastoma, and Parkinson's and Alzheimer's Diseases

Overview

Journal Front Cell Neurosci

Specialty Cell Biology

Date 2020 Dec 17

PMID 33328891

Citations 10

Authors

Laura Thomas

Tullio Florio

Carolina Perez-Castro

Affiliations

Soon will be listed here.

Abstract

Glioblastoma (GBM) is the deadliest brain tumor. Its poor prognosis is due to cell heterogeneity, invasiveness, and high vascularization that impede an efficient therapeutic approach. In the past few years, several molecular links connecting GBM to neurodegenerative diseases (NDDs) were identified at preclinical and clinical level. In particular, giving the increasing critical role that epigenetic alterations play in both GBM and NDDs, we deeply analyzed the role of miRNAs, small non-coding RNAs acting epigenetic modulators in several key biological processes. Specific miRNAs, transported by extracellular vesicles (EVs), act as intercellular communication signals in both diseases. In this way, miRNA-loaded EVs modulate GBM tumorigenesis, as they spread oncogenic signaling within brain parenchyma, and control the aggregation of neurotoxic protein (Tau, Aβ-amyloid peptide, and α-synuclein) in NDDs. In this review, we highlight the most promising miRNAs linking GBM and NDDs playing a significant pathogenic role in both diseases.

Citing Articles

A bird's eye view to the homeostatic, Alzheimer and Glioblastoma attractors.

Nieves J, Gil G, Gonzalez A Heliyon. 2025; 11(4):e42445.

PMID: 40028606 PMC: 11867265. DOI: 10.1016/j.heliyon.2025.e42445.

Glioblastoma and Internal Carotid Artery Calcium Score: A Possible Novel Prognostic Partnership?.

Pasqualetti F, Gabelloni M, Faggioni L, Aquaro G, De Vietro F, Mendola V J Clin Med. 2024; 13(5).

PMID: 38592330 PMC: 10933913. DOI: 10.3390/jcm13051512.

is a Potential Biomarker and Therapeutic Target for Glioblastoma.

Huang X, Xu C, Dai H, Yang J, Huang T, Chen S J Cancer. 2024; 15(4):1067-1076.

PMID: 38230206 PMC: 10788732. DOI: 10.7150/jca.90535.

microRNAs (miRNAs) in Glioblastoma Multiforme (GBM)-Recent Literature Review.

Makowska M, Smolarz B, Romanowicz H Int J Mol Sci. 2023; 24(4).

PMID: 36834933 PMC: 9965735. DOI: 10.3390/ijms24043521.

Extracellular vesicles released from macrophages modulates interleukin-1β in astrocytic and neuronal cells.

Kodidela S, Sinha N, Kumar A, Zhou L, Godse S, Kumar S Sci Rep. 2023; 13(1):3005.

PMID: 36810605 PMC: 9944928. DOI: 10.1038/s41598-023-29746-y.

References

Zhang J, Li S, Li L, Li M, Guo C, Yao J . Exosome and exosomal microRNA: trafficking, sorting, and function. Genomics Proteomics Bioinformatics. 2015; 13(1):17-24. PMC: 4411500. DOI: 10.1016/j.gpb.2015.02.001. View

Moutinho C, Esteller M . MicroRNAs and Epigenetics. Adv Cancer Res. 2017; 135:189-220. DOI: 10.1016/bs.acr.2017.06.003. View

Bazrgar M, Khodabakhsh P, Mohagheghi F, Prudencio M, Ahmadiani A . Brain microRNAs dysregulation: Implication for missplicing and abnormal post-translational modifications of tau protein in Alzheimer's disease and related tauopathies. Pharmacol Res. 2020; 155:104729. DOI: 10.1016/j.phrs.2020.104729. View

Lisi L, Ciotti G, Braun D, Kalinin S, Curro D, Dello Russo C . Expression of iNOS, CD163 and ARG-1 taken as M1 and M2 markers of microglial polarization in human glioblastoma and the surrounding normal parenchyma. Neurosci Lett. 2017; 645:106-112. DOI: 10.1016/j.neulet.2017.02.076. View

Xu G, Zhang B, Ye J, Cao S, Shi J, Zhao Y . Exosomal miRNA-139 in cancer-associated fibroblasts inhibits gastric cancer progression by repressing MMP11 expression. Int J Biol Sci. 2019; 15(11):2320-2329. PMC: 6775321. DOI: 10.7150/ijbs.33750. View

Wang N, Tan H, Feng Y, Zhang C, Chen F, Feng Y . microRNA-23a in Human Cancer: Its Roles, Mechanisms and Therapeutic Relevance. Cancers (Basel). 2018; 11(1). PMC: 6356664. DOI: 10.3390/cancers11010007. View

Li Y, Huang Y, Qi Z, Sun T, Zhou Y . MiR-338-5p Promotes Glioma Cell Invasion by Regulating TSHZ3 and MMP2. Cell Mol Neurobiol. 2017; 38(3):669-677. PMC: 11482023. DOI: 10.1007/s10571-017-0525-x. View

Zhou Y, Lu M, Du R, Qiao C, Jiang C, Zhang K . MicroRNA-7 targets Nod-like receptor protein 3 inflammasome to modulate neuroinflammation in the pathogenesis of Parkinson's disease. Mol Neurodegener. 2016; 11:28. PMC: 4833896. DOI: 10.1186/s13024-016-0094-3. View

Zayas-Santiago A, Diaz-Garcia A, Nunez-Rodriguez R, Inyushin M . Accumulation of amyloid beta in human glioblastomas. Clin Exp Immunol. 2020; 202(3):325-334. PMC: 7670151. DOI: 10.1111/cei.13493. View

10.

Rivera-Diaz M, Miranda-Roman M, Soto D, Quintero-Aguilo M, Ortiz-Zuazaga H, Marcos-Martinez M . MicroRNA-27a distinguishes glioblastoma multiforme from diffuse and anaplastic astrocytomas and has prognostic value. Am J Cancer Res. 2015; 5(1):201-18. PMC: 4300691. View

11.

Xu G, Li J . Differential expression of PDGFRB and EGFR in microvascular proliferation in glioblastoma. Tumour Biol. 2016; 37(8):10577-86. DOI: 10.1007/s13277-016-4968-3. View

12.

Yue S, Wang L, Zhang H, Min Y, Lou Y, Sun H . miR-139-5p suppresses cancer cell migration and invasion through targeting ZEB1 and ZEB2 in GBM. Tumour Biol. 2015; 36(9):6741-9. DOI: 10.1007/s13277-015-3372-8. View

13.

DUrso P, DUrso O, Damiano Gianfreda C, Mezzolla V, Storelli C, Marsigliante S . miR-15b and miR-21 as Circulating Biomarkers for Diagnosis of Glioma. Curr Genomics. 2016; 16(5):304-11. PMC: 4763968. DOI: 10.2174/1389202916666150707155610. View

14.

Ingenito F, Roscigno G, Affinito A, Nuzzo S, Scognamiglio I, Quintavalle C . The Role of Exo-miRNAs in Cancer: A Focus on Therapeutic and Diagnostic Applications. Int J Mol Sci. 2019; 20(19). PMC: 6801421. DOI: 10.3390/ijms20194687. View

15.

Bajetto A, Thellung S, Dellacasagrande I, Pagano A, Barbieri F, Florio T . Cross talk between mesenchymal and glioblastoma stem cells: Communication beyond controversies. Stem Cells Transl Med. 2020; 9(11):1310-1330. PMC: 7581451. DOI: 10.1002/sctm.20-0161. View

16.

Teplyuk N, Uhlmann E, Gabriely G, Volfovsky N, Wang Y, Teng J . Therapeutic potential of targeting microRNA-10b in established intracranial glioblastoma: first steps toward the clinic. EMBO Mol Med. 2016; 8(3):268-87. PMC: 4772951. DOI: 10.15252/emmm.201505495. View

17.

Chen J, Li Y, Yu T, McKay R, Burns D, Kernie S . A restricted cell population propagates glioblastoma growth after chemotherapy. Nature. 2012; 488(7412):522-6. PMC: 3427400. DOI: 10.1038/nature11287. View

18.

Xiong Y, Tang Y, Fan F, Zeng Y, Li C, Zhou G . Exosomal hsa-miR-21-5p derived from growth hormone-secreting pituitary adenoma promotes abnormal bone formation in acromegaly. Transl Res. 2019; 215:1-16. DOI: 10.1016/j.trsl.2019.07.013. View

19.

Manini I, Caponnetto F, Bartolini A, Ius T, Mariuzzi L, Di Loreto C . Role of Microenvironment in Glioma Invasion: What We Learned from In Vitro Models. Int J Mol Sci. 2018; 19(1). PMC: 5796096. DOI: 10.3390/ijms19010147. View

20.

Babae N, Bourajjaj M, Liu Y, van Beijnum J, Cerisoli F, Scaria P . Systemic miRNA-7 delivery inhibits tumor angiogenesis and growth in murine xenograft glioblastoma. Oncotarget. 2014; 5(16):6687-700. PMC: 4196156. DOI: 10.18632/oncotarget.2235. View