The Promise of Mesenchymal Stromal/stem Cells in Erectile Dysfunction Treatment: a Review of Current Insights and Future Directions

Overview

Journal Stem Cell Res Ther

Publisher Biomed Central

Date 2025 Feb 26

PMID 40012076

Authors

Ayyub Ali Patel

Alaa Shafie

Asmaa H Mohamed

Sana Abdul-Jabbar Ali

Faris J Tayeb

Hisham Ali Waggiallah

Irfan Ahmad

Salah Ahmed Sheweita

Khursheed Muzammil

Abdullah M AlShahrani

Waleed Al Abdulmonem

Affiliations

Soon will be listed here.

Abstract

Erectile dysfunction is a common and multifactorial condition that significantly impacts men's quality of life. Traditional treatments, such as phosphodiesterase type 5 inhibitors (PDE5i), often fail to provide lasting benefits, particularly in patients with underlying health conditions. In recent years, regenerative medicine, particularly stem cell therapies, has emerged as a promising alternative for managing erectile dysfunction. This review explores the potential of mesenchymal stromal/stem cells (MSCs) and their paracrine effects, including extracellular vesicles (EVs), in the treatment of erectile dysfunction. MSCs have shown remarkable potential in promoting tissue repair, reducing inflammation, and regenerating smooth muscle cells, offering therapeutic benefits in models of erectile dysfunction. Clinical trials have demonstrated positive outcomes in improving erectile function and other clinical parameters. This review highlights the promise of MSC therapy for erectile dysfunction, discusses existing challenges, and emphasizes the need for continued research to refine these therapies and improve long-term patient outcomes.

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