Sources and Clinical Applications of Mesenchymal Stem Cells: State-of-the-art Review

Overview

Journal Sultan Qaboos Univ Med J

Specialty General Medicine

Date 2019 Jan 5

PMID 30607265

Citations 199

Authors

Roberto Berebichez-Fridman

Pablo R Montero-Olvera

Affiliations

Soon will be listed here.

Abstract

First discovered by Friedenstein in 1976, mesenchymal stem cells (MSCs) are adult stem cells found throughout the body that share a fixed set of characteristics. Discovered initially in the bone marrow, this cell source is considered the gold standard for clinical research, although various other sources-including adipose tissue, dental pulp, mobilised peripheral blood and birth-derived tissues-have since been identified. Although similar, MSCs derived from different sources possess distinct characteristics, advantages and disadvantages, including their differentiation potential and proliferation capacity, which influence their applicability. Hence, they may be used for specific clinical applications in the fields of regenerative medicine and tissue engineering. This review article summarises current knowledge regarding the various sources, characteristics and therapeutic applications of MSCs.

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