A Framework of Biomarkers for Skeletal Aging: a Consensus Statement by the Aging Biomarker Consortium

Overview

Journal Life Med

Date 2025 Jan 28

PMID 39872060

Authors

Jinlong Suo

Yibo Gan

Yangli Xie

Shuqin Xu

Jianfang Wang

Di Chen

Lin Chen

Lianfu Deng

Shiqing Feng

Jingdong Jackie Han

Qing Jiang

Guanghua Lei

Peng Liu

Xianghang Luo

Xin Ma

Jing Qu

Chunli Song

Peifu Tang

Tingting Tang

Sijia Wang

Xiaochun Wei

Chengtie Wu

Guozhi Xiao

Liu Yang

Licheng Zhang

Weiqi Zhang

Zhenlin Zhang

Guang-Hui Liu

Changqing Zhang

Gang Pei

Jian Luo

Rui Yue

Weiguo Zou

Affiliations

Soon will be listed here.

Abstract

The skeleton is an important structural and metabolic organ in human body, while aging is the physiological basis for degenerative skeletal diseases. China has the largest aging population in the world and faces great challenges in preventing and managing diseases related to skeletal aging. To address these challenges, the Aging China Biomarkers Consortium (ABC) has reached an expert consensus on biomarkers of skeletal aging by synthesizing the literature and insights from scientists and clinicians. The consensus provides a comprehensive assessment of biomarkers associated with skeletal aging and proposes a systematic framework that categorizes biomarkers into three dimensions, namely, functional, structural, and humoral dimensions. Within each dimension, the ABC recommended clinical and evidential research-based biomarkers for physiological aging and degenerative pathologies of the skeleton. This expert consensus aims to lay the foundation for future studies to assess the prediction, diagnosis, early warning, and treatment of diseases associated with skeletal aging, with the ultimate goal of improving the skeletal health of elderly populations in China and around the world.

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