The Multicentre Acute Ischemic Stroke ImaGIng and Clinical Data (MAGIC) Repository: Rationale and Blueprint

Overview

Journal Front Neuroinform

Date 2025 Jan 22

PMID 39839853

Authors

Hakim Baazaoui

Stefan T Engelter

Henrik Gensicke

Lukas S Enz

Marios Psychogios

Matthias Mutke

Patrik Michel

Davide Strambo

Alexander Salerno

Henk A Marquering

Paul J Nederkoorn

Nabila Wali

Stephanie Tanadini-Lang

Bjorn Menze

Ezequiel de la Rosa

Kaiyuan Yang

Gian Marco De Marchis

Tolga D Dittrich

Francesco Valletta

Manon Germann

Carlo W Cereda

Joao Pedro Marto

Lisa Herzog

Patrick Hirschi

Zsolt Kulcsar

Susanne Wegener

Affiliations

Soon will be listed here.

Abstract

Purpose: The Multicentre Acute ischemic stroke imaGIng and Clinical data (MAGIC) repository is a collaboration established in 2024 by seven stroke centres in Europe. MAGIC consolidates clinical and radiological data from acute ischemic stroke (AIS) patients who underwent endovascular therapy, intravenous thrombolysis, a combination of both, or conservative management.

Participants: All centres ensure accuracy and completeness of the data. Only patients who did not refuse use of their routine data collected during or after their hospital stay are included in the repository. Approvals or waivers are obtained from the responsible ethics committees before data exchange. A formal data transfer agreement (DTA) is signed by all contributing centres. The centres then share their data, and files are stored centrally on a safe server at the University Hospital Zurich. There, patient identifiers are removed and images are algorithmically de-faced. De-identified structured clinical data are connected to the imaging data by a new identifier. Data are made available to participating centres which have entered into a DTA for stroke research projects.

Repository Setup: Initially, MAGIC is set to comprise initial and first follow-up imaging of 2,500 AIS patients. Clinical data consist of a comprehensive set of patient characteristics and routine prehospital metrics, treatment and laboratory variables.

Outlook: Our repository will support research by leveraging the entire range of routinely collected imaging and clinical data. This dataset reflects the current state of practice in stroke patient evaluation and management and will enable researchers to retrospectively study clinically relevant questions outside the scope of randomized controlled clinical trials. New centres are invited to join MAGIC if they meet the requirements outlined here. We aim to reach approximately 10,000 cases by 2026.

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