Cohort Profile: Thrombolysis in Ischemic Stroke Patients (TRISP): a Multicentre Research Collaboration

Overview

Journal BMJ Open

Specialty General Medicine

Date 2018 Sep 19

PMID 30224398

Citations 10

Authors

Jan F Scheitz

Henrik Gensicke

Sanne M Zinkstok

Sami Curtze

Marcel Arnold

Christian Hametner

Alessandro Pezzini

Guillaume Turc

Andrea Zini

Visnja Padjen

Susanne Wegener

Annika Nordanstig

Lars Kellert

Georg Kagi

Yannick Bejot

Patrik Michel

Didier Leys

Christian H Nolte

Paul J Nederkoorn

Stefan T Engelter

Affiliations

Soon will be listed here.

Abstract

Purpose: The ThRombolysis in Ischemic Stroke Patients (TRISP) collaboration aims to address clinically relevant questions about safety and outcomes of intravenous thrombolysis (IVT) and endovascular thrombectomy. The findings can provide observational information on treatment of patients derived from everyday clinical practice.

Participants: TRISP is an open, investigator-driven collaborative research initiative of European stroke centres with expertise in treatment with revascularisation therapies and maintenance of hospital-based registries. All participating centres made a commitment to prospectively collect data on consecutive patients with stroke treated with IVT using standardised definitions of variables and outcomes, to assure accuracy and completeness of the data and to adapt their local databases to answer novel research questions.

Findings To Date: Currently, TRISP comprises 18 centres and registers >10 000 IVT-treated patients. Prior TRISP projects provided evidence on the safety and functional outcome in relevant subgroups of patients who were excluded, under-represented or not specifically addressed in randomised controlled trials (ie, pre-existing disability, cervical artery dissections, stroke mimics, prior statin use), demonstrated deficits in organisation of acute stroke care (ie, IVT during non-working hours, effects of onset-to-door time on onset-to-needle time), evaluated the association between laboratory findings on outcome after IVT and served to develop risk estimation tools for prediction of haemorrhagic complications and functional outcome after IVT.

Future Plans: Further TRISP projects to increase knowledge of the effect and safety of revascularisation therapies in acute stroke are ongoing. TRISP welcomes participation and project proposals of further centres fulfilling the outlined requirements. In the future, TRISP will be extended to include patients undergoing endovascular thrombectomy.

Citing Articles

The Multicentre Acute ischemic stroke imaGIng and Clinical data (MAGIC) repository: rationale and blueprint.

Baazaoui H, Engelter S, Gensicke H, Enz L, Psychogios M, Mutke M Front Neuroinform. 2025; 18():1508161.

PMID: 39839853 PMC: 11747442. DOI: 10.3389/fninf.2024.1508161.

Intravenous thrombolysis in young adults with ischemic stroke: A cohort study from the international TRISP collaboration.

Nybondas M, Martinez-Majander N, Ringleb P, Ungerer M, Gumbinger C, Trussel S Eur Stroke J. 2024; :23969873241304305.

PMID: 39655742 PMC: 11632716. DOI: 10.1177/23969873241304305.

Outcome in acute ischemic stroke patients treated with intravenous thrombolysis - a retrospective and statistical analysis of five years' experience.

Botezat M, Caragea A, Popescu G, Rosu G, Zorila M, tenea-Cojan T Rom J Morphol Embryol. 2024; 65(3):449-455.

PMID: 39529338 PMC: 11657329. DOI: 10.47162/RJME.65.3.07.

IV Thrombolysis With or Without Endovascular Treatment for Suspected Ischemic Stroke in Patients With Intracranial Tumors.

Seystahl K, Martinez-Majander N, Salerno A, Beyeler M, Erdur H, Marto J Neurology. 2023; 101(12):e1241-e1255.

PMID: 37463747 PMC: 10516283. DOI: 10.1212/WNL.0000000000207624.

Safety and effectiveness of IV Thrombolysis in retinal artery occlusion: A multicenter retrospective cohort study.

Baumgartner P, Kook L, Altersberger V, Gensicke H, Ardila-Jurado E, Kagi G Eur Stroke J. 2023; 8(4):966-973.

PMID: 37421135 PMC: 10683723. DOI: 10.1177/23969873231185895.

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