Circadian Rhythm Disruption Exacerbates Autoimmune Uveitis: The Essential Role of PER1 in Treg Cell Metabolic Support for Stability and Function

Overview

Journal Adv Sci (Weinh)

Date 2025 Jan 17

PMID 39823532

Authors

Wenjie Zhu

Guanyu Chen

Zhiqiang Xiao

Minzhen Wang

Zhuang Li

Yuxun Shi

Xiaohui Luo

Zuoyi Li

Haixiang Huang

Xiaoqing Chen

Lingyi Liang

Dan Liang

Affiliations

Soon will be listed here.

Abstract

Circadian rhythm plays a critical role in the progression of autoimmune diseases. While our previous study demonstrated the therapeutic effects of melatonin in experimental autoimmune uveitis, the involvement of circadian rhythm remained unclear. Using a light-induced circadian rhythm disruption model, we showed that disrupted circadian rhythms exacerbate autoimmune uveitis by impairing the stability and function of Treg cells. Mechanistically, we identified the core clock gene Per1, which is significantly reduced under circadian disruption, is essential for Treg cell metabolism and immunoregulatory function. This study underscores the pivotal role of circadian rhythm-related Treg cells in autoimmune disease progression.

Citing Articles

Circadian Rhythm Disruption Exacerbates Autoimmune Uveitis: The Essential Role of PER1 in Treg Cell Metabolic Support for Stability and Function.

Zhu W, Chen G, Xiao Z, Wang M, Li Z, Shi Y Adv Sci (Weinh). 2025; 12(10):e2400004.

PMID: 39823532 PMC: 11904989. DOI: 10.1002/advs.202400004.

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