Mitochondrial Control of Immunity: Beyond ATP

Overview

Journal Nat Rev Immunol

Specialty Allergy & Immunology

Date 2017 Jul 4

PMID 28669986

Citations 179

Authors

Manan M Mehta

Samuel E Weinberg

Navdeep S Chandel

Affiliations

Soon will be listed here.

Abstract

Mitochondria are important signalling organelles, and they dictate immunological fate. From T cells to macrophages, mitochondria form the nexus of the various metabolic pathways that define each immune cell subset. In this central position, mitochondria help to control the various metabolic decision points that determine immune cell function. In this Review, we discuss how mitochondrial metabolism varies across different immune cell subsets, how metabolic signalling dictates cell fate and how this signalling could potentially be targeted therapeutically.

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