Relationship Between ABO Blood Groups and Mental Disorders

Overview

Journal J Blood Med

Publisher Dove Medical Press

Date 2025 Jan 9

PMID 39781374

Authors

Vladeta Ajdacic-Gross

Ana Buadze

En-Young N Wagner

Mario Muller

Erich Seifritz

Setareh Ranjbar

Jennifer Glaus

Enrique Castelao

Marie-Pierre F Strippoli

Caroline L Vandeleur

Martin Preisig

Roland von Kanel

Affiliations

Soon will be listed here.

Abstract

Previous research has unveiled an intriguing positive association between the AB blood group and mental disorders in general. In this study, we compared ABO blood groups with five major groups of mental disorders to attain a higher level of specificity. The analyses were conducted using data from the CoLaus|PsyCoLaus study (N=5111). They revealed that the AB blood group exhibited a positive association with both neurodevelopmental disorders (RR 2.29, CI 1.38-3.82) and substance use disorders (RR 2.25, CI 1.38-3.65) after adjusting for sex and childhood adversities. These associations could be replicated with respect to the familial aggregation of neurodevelopmental and substance use disorders. Large databases are needed to achieve more detailed results related to specific disorders.

References

Ajdacic-Gross V, Mutsch M, Rodgers S, Tesic A, Muller M, Seifritz E . A step beyond the hygiene hypothesis-immune-mediated classes determined in a population-based study. BMC Med. 2019; 17(1):75. PMC: 6454751. DOI: 10.1186/s12916-019-1311-z. View

Groot H, Villegas Sierra L, Said M, Lipsic E, Karper J, van der Harst P . Genetically Determined ABO Blood Group and its Associations With Health and Disease. Arterioscler Thromb Vasc Biol. 2020; 40(3):830-838. DOI: 10.1161/ATVBAHA.119.313658. View

Pfefferle P, Renz H . Microbial exposure and onset of allergic diseases - potential prevention strategies?. Allergol Int. 2014; 63(1):3-10. DOI: 10.2332/allergolint.13-RAI-0671. View

Vandeleur C, Rothen S, Jeanpretre N, Lustenberger Y, Gamma F, Ayer E . Inter-informant agreement and prevalence estimates for substance use disorders: direct interview versus family history method. Drug Alcohol Depend. 2007; 92(1-3):9-19. DOI: 10.1016/j.drugalcdep.2007.05.023. View

Kessler R, Aguilar-Gaxiola S, Alonso J, Chatterji S, Lee S, Ustun T . The WHO World Mental Health (WMH) Surveys. Psychiatrie (Stuttg). 2010; 6(1):5-9. PMC: 2995950. View

Cooling L . Blood Groups in Infection and Host Susceptibility. Clin Microbiol Rev. 2015; 28(3):801-70. PMC: 4475644. DOI: 10.1128/CMR.00109-14. View

Preisig M, Waeber G, Vollenweider P, Bovet P, Rothen S, Vandeleur C . The PsyCoLaus study: methodology and characteristics of the sample of a population-based survey on psychiatric disorders and their association with genetic and cardiovascular risk factors. BMC Psychiatry. 2009; 9:9. PMC: 2667506. DOI: 10.1186/1471-244X-9-9. View

Vuk Pisk S, Vuk T, Ivezic E, Jukic I, Bingulac-Popovic J, Filipcic I . ABO blood groups and psychiatric disorders: a Croatian study. Blood Transfus. 2018; 17(1):66-71. PMC: 6343596. DOI: 10.2450/2018.0266-17. View

Ewald D, Sumner S . Human microbiota, blood group antigens, and disease. Wiley Interdiscip Rev Syst Biol Med. 2018; 10(3):e1413. PMC: 5902424. DOI: 10.1002/wsbm.1413. View

10.

Rook G, Lowry C, Raison C . Microbial 'Old Friends', immunoregulation and stress resilience. Evol Med Public Health. 2014; 2013(1):46-64. PMC: 3868387. DOI: 10.1093/emph/eot004. View

11.

Kessler R, Berglund P, Demler O, Jin R, Merikangas K, Walters E . Lifetime prevalence and age-of-onset distributions of DSM-IV disorders in the National Comorbidity Survey Replication. Arch Gen Psychiatry. 2005; 62(6):593-602. DOI: 10.1001/archpsyc.62.6.593. View

12.

Angst J, Gamma A, Neuenschwander M, Ajdacic-Gross V, Eich D, Rossler W . Prevalence of mental disorders in the Zurich Cohort Study: a twenty year prospective study. Epidemiol Psichiatr Soc. 2005; 14(2):68-76. DOI: 10.1017/s1121189x00006278. View

13.

Hoglund J, Karlsson T, Johansson T, Ek W, Johansson A . Characterization of the human ABO genotypes and their association to common inflammatory and cardiovascular diseases in the UK Biobank. Am J Hematol. 2021; 96(11):1350-1362. DOI: 10.1002/ajh.26307. View

14.

Alexander K, Zakai N, Gillett S, McClure L, Wadley V, Unverzagt F . ABO blood type, factor VIII, and incident cognitive impairment in the REGARDS cohort. Neurology. 2014; 83(14):1271-6. PMC: 4180487. DOI: 10.1212/WNL.0000000000000844. View

15.

Ajdacic-Gross V, Muller M, Rodgers S, Warnke I, Hengartner M, Landolt K . The ZInEP Epidemiology Survey: background, design and methods. Int J Methods Psychiatr Res. 2014; 23(4):451-68. PMC: 6878317. DOI: 10.1002/mpr.1441. View

16.

Nurnberger Jr J, Blehar M, Kaufmann C, Simpson S, Harkavy-Friedman J, Severe J . Diagnostic interview for genetic studies. Rationale, unique features, and training. NIMH Genetics Initiative. Arch Gen Psychiatry. 1994; 51(11):849-59; discussion 863-4. DOI: 10.1001/archpsyc.1994.03950110009002. View

17.

Meldrum S, DVaz N, Dunstan J, Mori T, Hird K, Simmer K . Allergic disease in the first year of life is associated with differences in subsequent neurodevelopment and behaviour. Early Hum Dev. 2012; 88(7):567-73. DOI: 10.1016/j.earlhumdev.2011.12.032. View

18.

Preisig M, Fenton B, Matthey M, Berney A, Ferrero F . Diagnostic interview for genetic studies (DIGS): inter-rater and test-retest reliability of the French version. Eur Arch Psychiatry Clin Neurosci. 1999; 249(4):174-9. DOI: 10.1007/s004060050084. View

19.

Ajdacic-Gross V, Aleksandrowicz A, Rodgers S, Mutsch M, Tesic A, Muller M . Infectious, atopic and inflammatory diseases, childhood adversities and familial aggregation are independently associated with the risk for mental disorders: Results from a large Swiss epidemiological study. World J Psychiatry. 2017; 6(4):419-430. PMC: 5183994. DOI: 10.5498/wjp.v6.i4.419. View

20.

Liao T, Lien Y, Wang S, Huang S, Chen C . Comorbidity of Atopic Disorders with Autism Spectrum Disorder and Attention Deficit/Hyperactivity Disorder. J Pediatr. 2016; 171:248-55. DOI: 10.1016/j.jpeds.2015.12.063. View