Infectious, Atopic and Inflammatory Diseases, Childhood Adversities and Familial Aggregation Are Independently Associated with the Risk for Mental Disorders: Results from a Large Swiss Epidemiological Study

Overview

Journal World J Psychiatry

Publisher Baishideng Publishing Group

Specialty Psychiatry

Date 2017 Jan 13

PMID 28078206

Citations 9

Authors

Vladeta Ajdacic-Gross

Aleksandra Aleksandrowicz

Stephanie Rodgers

Margot Mutsch

Anja Tesic

Mario Muller

Wolfram Kawohl

Wulf Rossler

Erich Seifritz

Enrique Castelao

Marie-Pierre F Strippoli

Caroline Vandeleur

Roland von Kanel

Rosa Paolicelli

Markus A Landolt

Cornelia Witthauer

Roselind Lieb

Martin Preisig

Affiliations

Soon will be listed here.

Abstract

Aim: To examine the associations between mental disorders and infectious, atopic, inflammatory diseases while adjusting for other risk factors.

Methods: We used data from PsyCoLaus, a large Swiss Population Cohort Study ( = 3720; age range 35-66). Lifetime diagnoses of mental disorders were grouped into the following categories: Neurodevelopmental, anxiety (early and late onset), mood and substance disorders. They were regressed on infectious, atopic and other inflammatory diseases adjusting for sex, educational level, familial aggregation, childhood adversities and traumatic experiences in childhood. A multivariate logistic regression was applied to each group of disorders. In a complementary analysis interactions with sex were introduced nested effects.

Results: Associations with infectious, atopic and other chronic inflammatory diseases were observable together with consistent effects of childhood adversities and familial aggregation, and less consistent effects of trauma in each group of mental disorders. Streptococcal infections were associated with neurodevelopmental disorders (men), and measles/mumps/rubella-infections with early and late anxiety disorders (women). Gastric inflammatory diseases took effect in mood disorders (both sexes) and in early disorders (men). Similarly, irritable bowel syndrome was prominent in a sex-specific way in mood disorders in women, and, moreover, was associated with early and late anxiety disorders. Atopic diseases were associated with late anxiety disorders. Acne (associations with mood disorders in men) and psoriasis (associations with early anxiety disorders in men and mood disorders in women) contributed sex-specific results. Urinary tract infections were associated with mood disorders and, in addition, in a sex-specific way with late anxiety disorders (men), and neurodevelopmental and early anxiety disorders (women).

Conclusion: Infectious, atopic and inflammatory diseases are important risk factors for all groups of mental disorders. The sexual dimorphism of the associations is pronounced.

Citing Articles

Relationship Between ABO Blood Groups and Mental Disorders.

Ajdacic-Gross V, Buadze A, Wagner E, Muller M, Seifritz E, Ranjbar S J Blood Med. 2025; 16():1-5.

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Prenatal and early childhood infections requiring hospitalization and risk of neurodevelopmental disorders in offspring: a population-based birth cohort study in Taiwan.

Lin M, Pan Y, Wu C, Liu C, Chen P, Thompson W Mol Psychiatry. 2024; .

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Examining the Relationships between the Incidence of Infectious Diseases and Mood Disorders: An Analysis of Data from the Global Burden of Disease Studies, 1990-2019.

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Nonshared environmental factors in the aetiology of autism and other neurodevelopmental conditions: a monozygotic co-twin control study.

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References

Diani M, Altomare G, Reali E . T cell responses in psoriasis and psoriatic arthritis. Autoimmun Rev. 2014; 14(4):286-92. DOI: 10.1016/j.autrev.2014.11.012. View

Andreasen N, Endicott J, Spitzer R, Winokur G . The family history method using diagnostic criteria. Reliability and validity. Arch Gen Psychiatry. 1977; 34(10):1229-35. DOI: 10.1001/archpsyc.1977.01770220111013. View

Khandaker G, Zammit S, Lewis G, Jones P . A population-based study of atopic disorders and inflammatory markers in childhood before psychotic experiences in adolescence. Schizophr Res. 2013; 152(1):139-45. PMC: 3906534. DOI: 10.1016/j.schres.2013.09.021. View

Goodwin R, Fischer M, Goldberg J . A twin study of post-traumatic stress disorder symptoms and asthma. Am J Respir Crit Care Med. 2007; 176(10):983-7. DOI: 10.1164/rccm.200610-1467OC. View

Schwarz J, Bilbo S . Sex, glia, and development: interactions in health and disease. Horm Behav. 2012; 62(3):243-53. PMC: 3374064. DOI: 10.1016/j.yhbeh.2012.02.018. View

Paolicelli R, Bolasco G, Pagani F, Maggi L, Scianni M, Panzanelli P . Synaptic pruning by microglia is necessary for normal brain development. Science. 2011; 333(6048):1456-8. DOI: 10.1126/science.1202529. View

Berk M, Williams L, Jacka F, ONeil A, Pasco J, Moylan S . So depression is an inflammatory disease, but where does the inflammation come from?. BMC Med. 2013; 11:200. PMC: 3846682. DOI: 10.1186/1741-7015-11-200. View

Eaton W, Pedersen M, Nielsen P, Mortensen P . Autoimmune diseases, bipolar disorder, and non-affective psychosis. Bipolar Disord. 2010; 12(6):638-46. PMC: 2950824. DOI: 10.1111/j.1399-5618.2010.00853.x. View

Goodwin R, Robinson M, Sly P, McKeague I, Susser E, Zubrick S . Severity and persistence of asthma and mental health: a birth cohort study. Psychol Med. 2012; 43(6):1313-22. PMC: 3857579. DOI: 10.1017/S0033291712001754. View

10.

Goodwin R, Bandiera F, Steinberg D, Ortega A, Feldman J . Asthma and mental health among youth: etiology, current knowledge and future directions. Expert Rev Respir Med. 2012; 6(4):397-406. DOI: 10.1586/ers.12.34. View

11.

Goodwin R, Stein M . Generalized anxiety disorder and peptic ulcer disease among adults in the United States. Psychosom Med. 2002; 64(6):862-6. DOI: 10.1097/01.psy.0000038935.67401.f3. View

12.

Zhang X, Wang Y, Dong H, Xu Y, Zhang S . Induction of Microglial Activation by Mediators Released from Mast Cells. Cell Physiol Biochem. 2016; 38(4):1520-31. DOI: 10.1159/000443093. View

13.

Severance E, Alaedini A, Yang S, Halling M, Gressitt K, Stallings C . Gastrointestinal inflammation and associated immune activation in schizophrenia. Schizophr Res. 2012; 138(1):48-53. PMC: 4244845. DOI: 10.1016/j.schres.2012.02.025. View

14.

Goodwin R, Pagura J, Cox B, Sareen J . Asthma and mental disorders in Canada: impact on functional impairment and mental health service use. J Psychosom Res. 2010; 68(2):165-73. DOI: 10.1016/j.jpsychores.2009.06.005. View

15.

Goodwin R, Buka S . Childhood respiratory disease and the risk of anxiety disorder and major depression in adulthood. Arch Pediatr Adolesc Med. 2008; 162(8):774-80. DOI: 10.1001/archpedi.162.8.774. View

16.

Clemens J, Elliott M, Suttorp M, Berry S . Temporal ordering of interstitial cystitis/bladder pain syndrome and non-bladder conditions. Urology. 2012; 80(6):1227-31. PMC: 3804419. DOI: 10.1016/j.urology.2012.06.059. View

17.

Yolken R, Torrey E . Are some cases of psychosis caused by microbial agents? A review of the evidence. Mol Psychiatry. 2008; 13(5):470-9. DOI: 10.1038/mp.2008.5. View

18.

Kayser M, Dalmau J . Anti-NMDA receptor encephalitis, autoimmunity, and psychosis. Schizophr Res. 2014; 176(1):36-40. PMC: 4409922. DOI: 10.1016/j.schres.2014.10.007. View

19.

Schmitt J, Buske-Kirschbaum A, Roessner V . Is atopic disease a risk factor for attention-deficit/hyperactivity disorder? A systematic review. Allergy. 2010; 65(12):1506-24. DOI: 10.1111/j.1398-9995.2010.02449.x. View

20.

Bilbo S, Schwarz J . The immune system and developmental programming of brain and behavior. Front Neuroendocrinol. 2012; 33(3):267-86. PMC: 3484177. DOI: 10.1016/j.yfrne.2012.08.006. View