Organoids in Skin Wound Healing

Overview

Journal Burns Trauma

Publisher Oxford University Press

Date 2025 Jan 6

PMID 39759541

Authors

Zitong Wang

Feng Zhao

Hongxin Lang

Haiyue Ren

Qiqi Zhang

Xing Huang

Cai He

Chengcheng Xu

Chiyu Tan

Jiajie Ma

Shu Duan

Zhe Wang

Affiliations

Soon will be listed here.

Abstract

Stem cells (SCs) can self-replicate and differentiate into multiple lineages. Organoids, 3D cultures derived from SCs, can replicate the spatial structure and physiological characteristics of organs . Skin organoids can effectively simulate the physiological structure and function of skin tissue, reliably restoring the natural skin ecology in various environments. Skin organoids have been employed extensively in skin development and pathology research, offering valuable insights for drug screening. Moreover, they play crucial roles in skin regeneration and tissue repair. This in-depth review explores the construction and applications of skin organoids in wound healing, with a focus on their construction process, including skin appendage integration, and significant advancements in wound-healing research.

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