Microfluidics-Based Ionic Catch and Release Oligosaccharide Synthesis (ICROS-Microflow) to Expedite Glycosylation Chemistry

Overview

Journal JACS Au

Publisher American Chemical Society

Specialty Chemistry

Date 2024 Nov 29

PMID 39610727

Authors

Yao-Yao Zhang

Mattia Ghirardello

Ryan Williams

Adrian Silva Diaz

Javier Rojo

Josef Voglmeir

Javier Ramos-Soriano

M Carmen Galan

Affiliations

Soon will be listed here.

Abstract

A continuous microfluidic glycosylation strategy that requires no chromatography between steps and significantly expedites glycosylation chemistry is described. This practical approach incorporates the advantages of imidazolium-based chromatography-free purification and in situ mass spectrometry reaction monitoring to achieve fast reaction optimization and shorter reaction times. We demonstrate the utility of this strategy in the synthesis of a series of glycoside targets, including an α-(1,6)-trimannoside and a branched Man oligomannoside, within 1 day.

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