Recent Updates on the Secondary Metabolites from Fungi and Their Biological Activities (Covering 2019 to 2024)

Overview

Journal J Fungi (Basel)

Date 2024 Nov 26

PMID 39590697

Authors

Prosper Amuzu

Xiaoqian Pan

Xuwen Hou

Jiahang Sun

Muhammad Abubakar Jakada

Eromosele Odigie

Dan Xu

Daowan Lai

Ligang Zhou

Affiliations

Soon will be listed here.

Abstract

species are commonly found in soil, water, plants, and animals. A variety of secondary metabolites with multiple biological activities have been recently isolated from species, making fungi a treasure trove of bioactive compounds. This mini-review comprehensively highlights the newly isolated secondary metabolites produced by species and their various biological activities reported from 2019 to October 2024. About 276 novel metabolites were revealed from at least 21 species in this period. The main metabolites were nitrogen-containing compounds, polyketides, terpenoids, steroids, and phenolics. The species mostly belonged to plant endophytic, plant pathogenic, soil-derived, and marine-derived fungi. The metabolites mainly displayed antibacterial, antifungal, phytotoxic, antimalarial, anti-inflammatory, and cytotoxic activities, suggesting their medicinal and agricultural applications. This mini-review aims to increase the diversity of metabolites and their biological activities in order to accelerate their development and applications.

References

Zhu J, Xiong P, Li Z, Li J, Lin L, Fu X . Antifungal sesquiterpenes with post-harvest anthracnose control effect on bananas from the fungus . Nat Prod Res. 2021; 36(5):1245-1252. DOI: 10.1080/14786419.2021.1872569. View

Tan J, Peng W, Li M, Kang F, Zheng Y, Xu L . Three new metabolites from the endophyte T2-10. Nat Prod Res. 2023; :1-11. DOI: 10.1080/14786419.2023.2278158. View

Song Z, Sun Y, Xu S, Li G, Yuan C, Zhou K . Secondary metabolites from the Endophytic fungi F25 and their antifungal activities. Front Microbiol. 2023; 14:1127971. PMC: 9929939. DOI: 10.3389/fmicb.2023.1127971. View

Chen J, Bai X, Hua Y, Zhang H, Wang H . Fusariumins C and D, two novel antimicrobial agents from Fusarium oxysporum ZZP-R1 symbiotic on Rumex madaio Makino. Fitoterapia. 2019; 134:1-4. DOI: 10.1016/j.fitote.2019.01.016. View

Chen X, Wei J, Tang J, Wu B . Two New Prenylated Glycine Derivatives from the Marine-Derived Fungus Fusarium sp. TW56-10. Chem Biodivers. 2021; 19(2):e202100899. DOI: 10.1002/cbdv.202100899. View

Zhang M, Chen B, Dai H, Sun J, Liu H, Han J . Discovery of antifungal secondary metabolites from an intestinal fungus Fusarium sp. J Antibiot (Tokyo). 2023; 77(3):193-198. DOI: 10.1038/s41429-023-00692-1. View

Yue J, Wang R, Xu T, Wang J, Yu Y, Cai B . Novel phenolic metabolites isolated from plant endophytic fungus . Nat Prod Res. 2022; 38(2):336-340. DOI: 10.1080/14786419.2022.2116579. View

A Abdelhakim I, Motoyama T, Nogawa T, Mahmud F, Futamura Y, Takahashi S . Isolation of new lucilactaene derivatives from P450 monooxygenase and aldehyde dehydrogenase knockout Fusarium sp. RK97-94 strains and their biological activities. J Antibiot (Tokyo). 2022; 75(7):361-374. DOI: 10.1038/s41429-022-00529-3. View

Ma J, Du J, Zhang Y, Liu J, Feng T, He J . Natural imidazole alkaloids as antibacterial agents against Pseudomonas syringae pv. actinidiae isolated from kiwi endophytic fungus Fusarium tricinctum. Fitoterapia. 2021; 156:105070. DOI: 10.1016/j.fitote.2021.105070. View

10.

Kuang Q, Li Q, Lei L, Wang Y, Huang L, Dai Y . Proliferatins suppress lipopolysaccharide-induced inflammation via inhibition of the NF-κB and MAPK signaling pathways. Bioorg Chem. 2022; 124:105810. DOI: 10.1016/j.bioorg.2022.105810. View

11.

Chen D, Liu L, Lu Y, Chen S . Identification of fusarielin M as a novel inhibitor of Mycobacterium tuberculosis protein tyrosine phosphatase B (MptpB). Bioorg Chem. 2020; 106:104495. DOI: 10.1016/j.bioorg.2020.104495. View

12.

Wang Y, Ma N, Lu Y, Dai S, Song X, Li C . Structure Elucidation and Anti-Tumor Activities of Trichothecenes from Endophytic Fungus . Biomolecules. 2022; 12(6). PMC: 9220965. DOI: 10.3390/biom12060778. View

13.

Fu Z, Liu Y, Xu M, Yao X, Wang H, Zhang H . Absolute Configuration Determination of Two Diastereomeric Neovasifuranones A and B from R1 by a Combination of Mosher's Method and Chiroptical Approach. J Fungi (Basel). 2022; 8(1). PMC: 8779425. DOI: 10.3390/jof8010040. View

14.

Xue M, Hou X, Fu J, Zhang J, Wang J, Zhao Z . Recent Advances in Search of Bioactive Secondary Metabolites from Fungi Triggered by Chemical Epigenetic Modifiers. J Fungi (Basel). 2023; 9(2). PMC: 9961798. DOI: 10.3390/jof9020172. View

15.

Knowles S, Raja H, Roberts C, Oberlies N . Fungal-fungal co-culture: a primer for generating chemical diversity. Nat Prod Rep. 2022; 39(8):1557-1573. PMC: 9384855. DOI: 10.1039/d1np00070e. View

16.

Wang X, Kong D, Zhang H, Zou Y . Discovery of a polyketide carboxylate phytotoxin from a polyketide glycoside hybrid by β-glucosidase mediated ester bond hydrolysis. Chem Sci. 2024; . PMC: 11441467. DOI: 10.1039/d4sc05256k. View

17.

Perochon A, Doohan F . Trichothecenes and Fumonisins: Key Players in -Cereal Ecosystem Interactions. Toxins (Basel). 2024; 16(2). PMC: 10893083. DOI: 10.3390/toxins16020090. View

18.

Jiang C, Li J, Zhang J, Jin X, Yu B, Fang J . Isolation, Identification, and Activity Evaluation of Chemical Constituents from Soil Fungus Fusarium avenaceum SF-1502 and Endophytic Fungus Fusarium proliferatum AF-04. J Agric Food Chem. 2019; 67(7):1839-1846. DOI: 10.1021/acs.jafc.8b05576. View

19.

Li M, Yu R, Bai X, Wang H, Zhang H . Fusarium: a treasure trove of bioactive secondary metabolites. Nat Prod Rep. 2020; 37(12):1568-1588. DOI: 10.1039/d0np00038h. View

20.

Gutleb A, Morrison E, Murk A . Cytotoxicity assays for mycotoxins produced by Fusarium strains: a review. Environ Toxicol Pharmacol. 2011; 11(3-4):309-20. DOI: 10.1016/s1382-6689(02)00020-0. View