Novel Phenolic Metabolites Isolated from Plant Endophytic Fungus

Two new phenolic compounds Fusagunolics A () and B () were isolated from the plant endophytic fungus in addition to the previously known metabolites (3-6). The structures of these compounds was elucidated using a combination of spectroscopic analyses, including UV, HRESIMS, 1 D, and 2 D NMR, as well as electronic circular dichroism (ECD) and the optical rotatory dispersion (ORD). Further, the anti-inflammatory activity of all the compounds was evaluated to assess their capability to inhibit nitric oxide (NO) production by RAW 264.7 macrophages. The bioactive screening revealed that compounds and exhibited moderate inhibitory effects against NO production with the IC values 28.6 and 37.6 μM, respectively.