Prenatal Iodine Intake and Infant Temperament in a Multiethnic US Cohort

Overview

Journal Public Health Nutr

Publisher Cambridge University Press

Date 2024 Nov 6

PMID 39501816

Authors

Aderonke A Akinkugbe

Julia Duffy

Srimathi Kannan

Terryl J Hartman

Julio Landero

Michelle Bosquet Enlow

Robert O Wright

Xueying Zhang

Rosalind J Wright

Affiliations

Soon will be listed here.

Abstract

Objective: Maternal iodine plays a central role in fetal neurodevelopment. It is recommended that pregnant women consume sufficient levels of iodine to accommodate increased need for mother and fetus. We examined associations among prenatal dietary and supplemental iodine intake and infant temperament.

Design: The PRogramming of Intergenerational Stress Mechanisms (PRISM) study is an ongoing longitudinal pregnancy cohort. Data from 2011 to 2020 were used for this study. Women completed the Block98 FFQ ascertaining prenatal dietary and supplemental iodine intake and the Infant Behavior Questionnaire-Revised at infant age 6 months to ascertain infant temperament (Surgency/Extraversion, Negative Affectivity and Orienting/Regulation).

Setting: USA.

Participants: Mother-child dyads ( 892).

Results: Women were primarily Black/Hispanic Black (44 %) and non-Black Hispanic (35 %) with 46 % reporting household income < $25 000/year. Nearly half had an estimated average requirement (EAR) < 160 µg/d (49 % based on dietary intake; 43 % based on diet and supplements). Girls born to women with an EAR ≥ 160 µg/d compared to girls born to women below this level had higher unadjusted extraversion scores for dietary plus supplemental intake ( = 0·23 (0·13, 0·33)); decreased to = 0·05 (-0·08, 0·19) after adjusting for covariates. Boys born to women with an EAR ≥ 160 µg/d (based on diet and supplements) as compared to boys born to women below this level had statistically non-significant higher unadjusted negative affective score ( = 0·06 (-0·08, 0·20)) that became significantly lower upon covariate adjustment ( = -1·66 (-1·97, -1·35)).

Conclusions: A significant proportion of these women reported suboptimal prenatal iodine intake. Suboptimal prenatal iodine intake may have implications for child neurodevelopment evident as early as infancy.

References

Lee K, Shin D, Cho M, Song W . Food Group Intakes as Determinants of Iodine Status among US Adult Population. Nutrients. 2016; 8(6). PMC: 4924166. DOI: 10.3390/nu8060325. View

Lipton L, Brunst K, Kannan S, Ni Y, Ganguri H, Wright R . Associations among prenatal stress, maternal antioxidant intakes in pregnancy, and child temperament at age 30 months. J Dev Orig Health Dis. 2017; 8(6):638-648. PMC: 6075665. DOI: 10.1017/S2040174417000411. View

Caldwell K, Pan Y, Mortensen M, Makhmudov A, Merrill L, Moye J . Iodine status in pregnant women in the National Children's Study and in U.S. women (15-44 years), National Health and Nutrition Examination Survey 2005-2010. Thyroid. 2013; 23(8):927-37. PMC: 3752509. DOI: 10.1089/thy.2013.0012. View

Stifter C, Willoughby M, Towe-Goodman N . Agree or Agree to Disagree? Assessing the Convergence between Parents and Observers on Infant Temperament. Infant Child Dev. 2009; 17(4):407-426. PMC: 2779030. DOI: 10.1002/icd.584. View

Ershow A, Haggans C, Roseland J, Patterson K, Spungen J, Gahche J . Databases of Iodine Content of Foods and Dietary Supplements-Availability of New and Updated Resources. J Acad Nutr Diet. 2022; 122(7):1229-1231. DOI: 10.1016/j.jand.2022.03.017. View

Ceasrine A, Devlin B, Bolton J, Green L, Jo Y, Huynh C . Maternal diet disrupts the placenta-brain axis in a sex-specific manner. Nat Metab. 2022; 4(12):1732-1745. PMC: 10507630. DOI: 10.1038/s42255-022-00693-8. View

Mauvais-Jarvis F, Merz N, Barnes P, Brinton R, Carrero J, DeMeo D . Sex and gender: modifiers of health, disease, and medicine. Lancet. 2020; 396(10250):565-582. PMC: 7440877. DOI: 10.1016/S0140-6736(20)31561-0. View

Griebel-Thompson A, Sands S, Chollet-Hinton L, Christifano D, Sullivan D, Hull H . Iodine Intake From Diet and Supplements and Urinary Iodine Concentration in a Cohort of Pregnant Women in the United States. Am J Clin Nutr. 2023; 118(1):283-289. PMC: 10493429. DOI: 10.1016/j.ajcnut.2023.04.005. View

Pehrsson P, Roseland J, Patterson K, Phillips K, Spungen J, Andrews K . Iodine in Foods and Dietary Supplements: A Collaborative Database Developed by NIH, FDA and USDA. J Food Compost Anal. 2022; 109. PMC: 9365050. DOI: 10.1016/j.jfca.2021.104369. View

10.

Bale T, Baram T, Brown A, Goldstein J, Insel T, McCarthy M . Early life programming and neurodevelopmental disorders. Biol Psychiatry. 2010; 68(4):314-9. PMC: 3168778. DOI: 10.1016/j.biopsych.2010.05.028. View

11.

Kostyrka-Allchorne K, Wass S, Sonuga-Barke E . Research Review: Do parent ratings of infant negative emotionality and self-regulation predict psychopathology in childhood and adolescence? A systematic review and meta-analysis of prospective longitudinal studies. J Child Psychol Psychiatry. 2019; 61(4):401-416. DOI: 10.1111/jcpp.13144. View

12.

Bosquet Enlow M, Devick K, Brunst K, Lipton L, Coull B, Wright R . Maternal Lifetime Trauma Exposure, Prenatal Cortisol, and Infant Negative Affectivity. Infancy. 2017; 22(4):492-513. PMC: 5624542. DOI: 10.1111/infa.12176. View

13.

Khan B, Avan B . Behavioral problems in preadolescence: Does gender matter?. Psych J. 2020; 9(5):583-596. DOI: 10.1002/pchj.347. View

14.

Bosquet Enlow M, White M, Hails K, Cabrera I, Wright R . The Infant Behavior Questionnaire-Revised: Factor structure in a culturally and sociodemographically diverse sample in the United States. Infant Behav Dev. 2016; 43:24-35. PMC: 4909571. DOI: 10.1016/j.infbeh.2016.04.001. View

15.

Rothbart M, Ahadi S . Temperament and the development of personality. J Abnorm Psychol. 1994; 103(1):55-66. DOI: 10.1037//0021-843x.103.1.55. View

16.

Minghetti L, Greco A, Zanardo V, Suppiej A . Early-life sex-dependent vulnerability to oxidative stress: the natural twining model. J Matern Fetal Neonatal Med. 2012; 26(3):259-62. DOI: 10.3109/14767058.2012.733751. View

17.

Kerver J, Pearce E, Ma T, Gentchev M, Elliott M, Paneth N . Prevalence of inadequate and excessive iodine intake in a US pregnancy cohort. Am J Obstet Gynecol. 2020; 224(1):82.e1-82.e8. PMC: 7779669. DOI: 10.1016/j.ajog.2020.06.052. View

18.

Gowachirapant S, Jaiswal N, Melse-Boonstra A, Galetti V, Stinca S, MacKenzie I . Effect of iodine supplementation in pregnant women on child neurodevelopment: a randomised, double-blind, placebo-controlled trial. Lancet Diabetes Endocrinol. 2017; 5(11):853-863. DOI: 10.1016/S2213-8587(17)30332-7. View

19.

Brunst K, Kannan S, Ni Y, Gennings C, Ganguri H, Wright R . Validation of a Food Frequency Questionnaire for Estimating Micronutrient Intakes in an Urban US Sample of Multi-Ethnic Pregnant Women. Matern Child Health J. 2015; 20(2):250-60. PMC: 4959268. DOI: 10.1007/s10995-015-1824-9. View

20.

White I, Royston P, Wood A . Multiple imputation using chained equations: Issues and guidance for practice. Stat Med. 2011; 30(4):377-99. DOI: 10.1002/sim.4067. View