ELO-6 Expression Predicts Longevity in Isogenic Populations of Caenorhabditis Elegans

Overview

Journal Nat Commun

Specialty Biology

Date 2024 Nov 3

PMID 39488532

Authors

Weilin Kong

Guoli Gu

Tong Dai

Beibei Chen

Yanli Wang

Zheng Zeng

Mintie Pu

Affiliations

Soon will be listed here.

Abstract

Variations of individual lifespans within genetically identical populations in homogenous environments are remarkable, with the cause largely unknown. Here, we show the expression dynamic of the Caenorhabditis elegans fatty acid elongase ELO-6 during aging predicts individual longevity in isogenic populations. elo-6 expression is reduced with age. ELO-6 expression level exhibits obvious variation between individuals in mid-aged worms and is positively correlated with lifespan and health span. Interventions that prolong longevity enhance ELO-6 expression stability during aging, indicating ELO-6 is also a populational lifespan predictor. Differentially expressed genes between short-lived and long-lived isogenic worms regulate lifespan and are enriched for PQM-1 binding sites. pqm-1 in young to mid-aged adults causes individual ELO-6 expression heterogeneity and restricts health span and life span. Thus, our study identifies ELO-6 as a predictor of individual and populational lifespan and reveals the role of pqm-1 in causing individual health span variation in the mid-aged C. elegans.

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