Reference Values for Cerebral and Peripheral Tissue Oximetry in Children: A Clinical TD-NIRS Study

Overview

Journal Acta Paediatr

Specialty Pediatrics

Date 2024 Oct 19

PMID 39425553

Authors

Valeria Calcaterra

Michele Lacerenza

Virginia Rossi

Sara Zanelli

Davide Contini

Caterina Amendola

Mauro Buttafava

Alessandro Torricelli

Gianvincenzo Zuccotti

Affiliations

Soon will be listed here.

Abstract

Aim: Current non-invasive near-infrared spectroscopy (NIRS) tissue oximetry suffers from suboptimal reproducibility over probe repositioning, hindering clinical threshold establishment. Time Domain-NIRS (TD-NIRS) offers higher precision but lacks sufficient paediatric data, preventing effective clinical application. We aimed to establish reference ranges for cerebral and mid-upper arm (MUA) tissue haemodynamics in paediatric subjects using TD-NIRS and explore correlations with auxological variables.

Methods: TD-NIRS measurements were conducted acquiring data from cerebral and MUA regions with the NIRSBOX tissue oximeter. Morphological and clinically relevant information were collected to explore potential correlations with TD-NIRS derived parameters.

Results: TD-NIRS assessment was applied in 350 children (8.4 ± 5.0 years). Precision of TD-NIRS was demonstrated with standard deviations of 0.9% (StO) and 4.2 μM (tHb) for frontotemporal cerebral cortex, and 0.8% (StO) and 3.7 μM (tHb) for MUA. No user dependency was observed. The trends of values for cerebral and peripheral regions vary differently according to age and auxological parameters.

Conclusion: This study reports resting-state optical and haemodynamic values for a healthy paediatric population, providing a foundation for future investigations into clinically relevant deviations in these parameters. Furthermore, correlations with anthropometric and demographic values provide valuable insights for a deeper understanding of tissue haemodynamic evolution in childhood.

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PMID: 40017478 PMC: 11864066. DOI: 10.2478/jccm-2025-0001.

Reference values for cerebral and peripheral tissue oximetry in children: A clinical TD-NIRS study.

Calcaterra V, Lacerenza M, Rossi V, Zanelli S, Contini D, Amendola C Acta Paediatr. 2024; 114(3):515-525.

PMID: 39425553 PMC: 11828717. DOI: 10.1111/apa.17459.

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