PRMT5: Splicing Up Tolerance

Overview

Journal J Clin Invest

Specialty General Medicine

Date 2024 Oct 15

PMID 39403925

Authors

Rathan Kumar

Parvathi Ranganathan

Affiliations

Soon will be listed here.

Abstract

Expression of tissue-restricted antigens (TRAs) within the thymus is critical for the establishment of self-tolerance; however, exact mechanisms regulating the expression of TRAs has proven more complex than previously appreciated. In this issue of the JCI, Muro et al. identify a central role for protein arginine methyltransferase 5 (PRMT5) in posttranscriptional regulation of TRAs and thereby central tolerance. Using conditional KO mice, the authors showed that thymic deficiency of Prmt5 predisposed mice to developing autoimmune diseases while enhancing antitumor efficacy. These studies provide insight into the role of PRMT5 in shaping the T cell repertoire with implications for the development of therapies.

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