Protein Arginine Methyltransferases and Cancer

Overview

Journal Nat Rev Cancer

Specialty Oncology

Date 2012 Dec 14

PMID 23235912

Citations 560

Authors

Yanzhong Yang

Mark T Bedford

Affiliations

Soon will be listed here.

Abstract

There are nine protein arginine methyltransferases (PRMTs) encoded in mammalian genomes, the protein products of which catalyse three types of arginine methylation--monomethylation and two types of dimethylation. Protein arginine methylation is an abundant modification that has been implicated in signal transduction, gene transcription, DNA repair and mRNA splicing, among others. Studies have only recently linked this modification to carcinogenesis and metastasis. Sequencing studies have not generally found alterations to the PRMTs; however, overexpression of these enzymes is often associated with various cancers, which might make some of them viable targets for therapeutic strategies.

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