Chemical Shift-encoded Multishot EPI for Navigator-free Prostate DWI

Overview

Journal Magn Reson Med

Publisher Wiley

Specialty Radiology

Date 2024 Oct 15

PMID 39402739

Authors

Yiming Dong

David Atkinson

Kirsten Koolstra

Matthias J P van Osch

Peter Bornert

Affiliations

Soon will be listed here.

Abstract

Purpose: DWI is an important contrast for prostate MRI to enable early and accurate detection of cancer. This study introduces a Dixon 3-shot-EPI protocol with structured low-rank reconstruction for navigator-free DWI. The aim is to overcome the limitations of single-shot EPI (ssh-EPI), such as geometric distortions and fat signal interference, while addressing the motion-induced phase variations of multishot EPI and simultaneously allowing water/fat separation.

Methods: DWI data were acquired from 7 healthy volunteers using both Dixon 3-shot EPI and standard fat-suppressed ssh-EPI with similar scan times for comparison. Two readers evaluated image quality using a 5-point Likert scale regarding different aspects. The ADC values were quantitatively compared between protocols. To show feasibility in a clinical setting, the protocol was applied to two patients.

Results: From the reader scores, Dixon 3-shot EPI significantly reduced geometric distortion compared with ssh-EPI (p < 0.01), with no significant differences in edge definition, SNR, or overall image quality. There was no significant difference in ADC values between the two protocols. However, the Dixon multishot-EPI protocol offered advantages such as self-referenced B map-driven distortion correction, greater flexibility in imaging parameters, and superior fat suppression. In the patient data, the lesion could be clearly identified in both protocols and on the associated ADC maps.

Conclusion: The proposed Dixon 3-shot-EPI protocol shows promise as an alternative to ssh-EPI for prostate DWI, providing reduced geometric distortions and improved fat suppression. It addresses common DWI issues based on EPI and enhances scanning flexibility, indicating potential for optimized imaging.

Citing Articles

Chemical shift-encoded multishot EPI for navigator-free prostate DWI.

Dong Y, Atkinson D, Koolstra K, van Osch M, Bornert P Magn Reson Med. 2024; 93(3):1059-1076.

PMID: 39402739 PMC: 11680737. DOI: 10.1002/mrm.30334.

References

Chen N, Guidon A, Chang H, Song A . A robust multi-shot scan strategy for high-resolution diffusion weighted MRI enabled by multiplexed sensitivity-encoding (MUSE). Neuroimage. 2013; 72:41-7. PMC: 3602151. DOI: 10.1016/j.neuroimage.2013.01.038. View

Eichner C, Cauley S, Cohen-Adad J, Moller H, Turner R, Setsompop K . Real diffusion-weighted MRI enabling true signal averaging and increased diffusion contrast. Neuroimage. 2015; 122:373-84. PMC: 4651971. DOI: 10.1016/j.neuroimage.2015.07.074. View

Tamada T, Kido A, Ueda Y, Takeuchi M, Kanki A, Neelavalli J . Comparison of single-shot EPI and multi-shot EPI in prostate DWI at 3.0 T. Sci Rep. 2022; 12(1):16070. PMC: 9515065. DOI: 10.1038/s41598-022-20518-8. View

Tan W, Lin C, Chen M, Deane L . Periprostatic Fat: A Risk Factor for Prostate Cancer?. Urology. 2016; 98:107-112. DOI: 10.1016/j.urology.2016.07.042. View

Dong Y, Koolstra K, Li Z, Riedel M, van Osch M, Bornert P . Structured low-rank reconstruction for navigator-free water/fat separated multi-shot diffusion-weighted EPI. Magn Reson Med. 2023; 91(1):205-220. DOI: 10.1002/mrm.29848. View

Avants B, Epstein C, Grossman M, Gee J . Symmetric diffeomorphic image registration with cross-correlation: evaluating automated labeling of elderly and neurodegenerative brain. Med Image Anal. 2007; 12(1):26-41. PMC: 2276735. DOI: 10.1016/j.media.2007.06.004. View

Reeder S, Pineda A, Wen Z, Shimakawa A, Yu H, Brittain J . Iterative decomposition of water and fat with echo asymmetry and least-squares estimation (IDEAL): application with fast spin-echo imaging. Magn Reson Med. 2005; 54(3):636-44. DOI: 10.1002/mrm.20624. View

Attenberger U, Rathmann N, Sertdemir M, Riffel P, Weidner A, Kannengiesser S . Small Field-of-view single-shot EPI-DWI of the prostate: Evaluation of spatially-tailored two-dimensional radiofrequency excitation pulses. Z Med Phys. 2015; 26(2):168-76. DOI: 10.1016/j.zemedi.2015.06.013. View

Hoeks C, Barentsz J, Hambrock T, Yakar D, Somford D, Heijmink S . Prostate cancer: multiparametric MR imaging for detection, localization, and staging. Radiology. 2011; 261(1):46-66. DOI: 10.1148/radiol.11091822. View

10.

Hu Z, Wang Y, Dong Z, Guo H . Water/fat separation for distortion-free EPI with point spread function encoding. Magn Reson Med. 2019; 82(1):251-262. DOI: 10.1002/mrm.27717. View

11.

Atkinson D, Porter D, Hill D, Calamante F, Connelly A . Sampling and reconstruction effects due to motion in diffusion-weighted interleaved echo planar imaging. Magn Reson Med. 2000; 44(1):101-9. DOI: 10.1002/1522-2594(200007)44:1<101::aid-mrm15>3.0.co;2-s. View

12.

Skare S, Hartwig A, Martensson M, Avventi E, Engstrom M . Properties of a 2D fat navigator for prospective image domain correction of nodding motion in brain MRI. Magn Reson Med. 2014; 73(3):1110-9. DOI: 10.1002/mrm.25234. View

13.

Hernando D, Karampinos D, King K, Haldar J, Majumdar S, Georgiadis J . Removal of olefinic fat chemical shift artifact in diffusion MRI. Magn Reson Med. 2011; 65(3):692-701. PMC: 3069507. DOI: 10.1002/mrm.22670. View

14.

Reeder S, Wen Z, Yu H, Pineda A, Gold G, Markl M . Multicoil Dixon chemical species separation with an iterative least-squares estimation method. Magn Reson Med. 2004; 51(1):35-45. DOI: 10.1002/mrm.10675. View

15.

Maurer M, Heverhagen J . Diffusion weighted imaging of the prostate-principles, application, and advances. Transl Androl Urol. 2017; 6(3):490-498. PMC: 5503962. DOI: 10.21037/tau.2017.05.06. View

16.

Kaye E, Aherne E, Duzgol C, Haggstrom I, Kobler E, Mazaheri Y . Accelerating Prostate Diffusion-weighted MRI Using a Guided Denoising Convolutional Neural Network: Retrospective Feasibility Study. Radiol Artif Intell. 2020; 2(5):e200007. PMC: 7529434. DOI: 10.1148/ryai.2020200007. View

17.

Guo H, Ma X, Zhang Z, Zhang B, Yuan C, Huang F . POCS-enhanced inherent correction of motion-induced phase errors (POCS-ICE) for high-resolution multishot diffusion MRI. Magn Reson Med. 2015; 75(1):169-80. DOI: 10.1002/mrm.25594. View

18.

Jeong H, Gore J, Anderson A . High-resolution human diffusion tensor imaging using 2-D navigated multishot SENSE EPI at 7 T. Magn Reson Med. 2012; 69(3):793-802. PMC: 3424313. DOI: 10.1002/mrm.24320. View

19.

An H, Ma X, Pan Z, Guo H, Lee E . Qualitative and quantitative comparison of image quality between single-shot echo-planar and interleaved multi-shot echo-planar diffusion-weighted imaging in female pelvis. Eur Radiol. 2019; 30(4):1876-1884. PMC: 7062860. DOI: 10.1007/s00330-019-06491-3. View

20.

Manjon J, Coupe P, Concha L, Buades A, Collins D, Robles M . Diffusion weighted image denoising using overcomplete local PCA. PLoS One. 2013; 8(9):e73021. PMC: 3760829. DOI: 10.1371/journal.pone.0073021. View