Challenges and Opportunities of Poly(amino Acid) Nanomedicines in Cancer Therapy

Overview

Journal Nanomedicine (Lond)

Specialty Biotechnology

Date 2024 Oct 9

PMID 39381990

Authors

Yuce Li

Jing He

Jixiu Liu

Wooram Um

Jianxun Ding

Affiliations

Soon will be listed here.

Abstract

Poly(amino acid) nanomedicines hold significant promise for cancer therapy. However, their clinical translation has not matched the extensive efforts of scientists or the burgeoning body of research. The therapeutic outcomes with most nanomedicines often fall short of the promising results observed in animal experiments. This review explores the challenges faced in cancer therapy using poly(amino acid) nanomedicines, particularly addressing the controversies surrounding the enhanced permeability and retention effect and the lack of methods for controlled and reproducible mass production of poly(amino acid) nanomedicines. Furthermore, this review examines the opportunities emerging in this field due to the rapid advancements in artificial intelligence.

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