Future of the Particle Replication in Nonwetting Templates (PRINT) Technology

Overview

Journal Angew Chem Int Ed Engl

Specialty Chemistry

Date 2013 May 15

PMID 23670869

Citations 44

Authors

Jing Xu

Dominica H C Wong

James D Byrne

Kai Chen

Charles Bowerman

Joseph M DeSimone

Affiliations

Soon will be listed here.

Abstract

Particle replication in nonwetting templates (PRINT) is a continuous, roll-to-roll, high-resolution molding technology which allows the design and synthesis of precisely defined micro- and nanoparticles. This technology adapts the lithographic techniques from the microelectronics industry and marries these with the roll-to-roll processes from the photographic film industry to enable researchers to have unprecedented control over particle size, shape, chemical composition, cargo, modulus, and surface properties. In addition, PRINT is a GMP-compliant (GMP=good manufacturing practice) platform amenable for particle fabrication on a large scale. Herein, we describe some of our most recent work involving the PRINT technology for application in the biomedical and material sciences.

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References

Rolland J, van Dam R, Schorzman D, Quake S, DeSimone J . Solvent-resistant photocurable liquid fluoropolymers for microfluidic device fabrication [corrected]. J Am Chem Soc. 2004; 126(8):2322-3. DOI: 10.1021/ja031657y. View

Gratton S, Ropp P, Pohlhaus P, Luft J, Madden V, Napier M . The effect of particle design on cellular internalization pathways. Proc Natl Acad Sci U S A. 2008; 105(33):11613-8. PMC: 2575324. DOI: 10.1073/pnas.0801763105. View

Karnik R, Gu F, Basto P, Cannizzaro C, Dean L, Kyei-Manu W . Microfluidic platform for controlled synthesis of polymeric nanoparticles. Nano Lett. 2008; 8(9):2906-12. DOI: 10.1021/nl801736q. View

Langer R . New methods of drug delivery. Science. 1990; 249(4976):1527-33. DOI: 10.1126/science.2218494. View

Ying H, Zaks T, Wang R, Irvine K, Kammula U, Marincola F . Cancer therapy using a self-replicating RNA vaccine. Nat Med. 1999; 5(7):823-7. PMC: 1976249. DOI: 10.1038/10548. View

Gratton S, Williams S, Napier M, Pohlhaus P, Zhou Z, Wiles K . The pursuit of a scalable nanofabrication platform for use in material and life science applications. Acc Chem Res. 2008; 41(12):1685-95. PMC: 2645958. DOI: 10.1021/ar8000348. View

Wang J, Wang Y, Sheiko S, Betts D, DeSimone J . Tuning multiphase amphiphilic rods to direct self-assembly. J Am Chem Soc. 2011; 134(13):5801-6. DOI: 10.1021/ja2066187. View

Farokhzad O, Langer R . Impact of nanotechnology on drug delivery. ACS Nano. 2009; 3(1):16-20. DOI: 10.1021/nn900002m. View

KENIS , Ismagilov , Whitesides . Microfabrication inside capillaries using multiphase laminar flow patterning . Science. 1999; 285(5424):83-5. DOI: 10.1126/science.285.5424.83. View

10.

Kersey F, Merkel T, Perry J, Napier M, DeSimone J . Effect of aspect ratio and deformability on nanoparticle extravasation through nanopores. Langmuir. 2012; 28(23):8773-81. PMC: 3374061. DOI: 10.1021/la301279v. View

11.

Hampton M, Templeton J, DeSimone J . Direct patterning of CdSe quantum dots into sub-100 nm structures. Langmuir. 2010; 26(5):3012-5. DOI: 10.1021/la904787k. View

12.

Kofler R, Aberle J, Aberle S, Allison S, Heinz F, Mandl C . Mimicking live flavivirus immunization with a noninfectious RNA vaccine. Proc Natl Acad Sci U S A. 2004; 101(7):1951-6. PMC: 357033. DOI: 10.1073/pnas.0307145101. View

13.

Green M, Manikhas G, Orlov S, Afanasyev B, Makhson A, Bhar P . Abraxane, a novel Cremophor-free, albumin-bound particle form of paclitaxel for the treatment of advanced non-small-cell lung cancer. Ann Oncol. 2006; 17(8):1263-8. DOI: 10.1093/annonc/mdl104. View

14.

Wang J, Tian S, Petros R, Napier M, DeSimone J . The complex role of multivalency in nanoparticles targeting the transferrin receptor for cancer therapies. J Am Chem Soc. 2010; 132(32):11306-13. PMC: 2923393. DOI: 10.1021/ja1043177. View

15.

Merkel T, DeSimone J . Dodging drug-resistant cancer with diamonds. Sci Transl Med. 2011; 3(73):73ps8. DOI: 10.1126/scitranslmed.3002137. View

16.

Chang H, Yeh M . Clinical development of liposome-based drugs: formulation, characterization, and therapeutic efficacy. Int J Nanomedicine. 2012; 7:49-60. PMC: 3260950. DOI: 10.2147/IJN.S26766. View

17.

Glangchai L, Caldorera-Moore M, Shi L, Roy K . Nanoimprint lithography based fabrication of shape-specific, enzymatically-triggered smart nanoparticles. J Control Release. 2007; 125(3):263-72. DOI: 10.1016/j.jconrel.2007.10.021. View

18.

Abbasi S, Paul A, Prakash S . Investigation of siRNA-loaded polyethylenimine-coated human serum albumin nanoparticle complexes for the treatment of breast cancer. Cell Biochem Biophys. 2011; 61(2):277-87. DOI: 10.1007/s12013-011-9201-9. View

19.

Parrott M, Finniss M, Luft J, Pandya A, Gullapalli A, Napier M . Incorporation and controlled release of silyl ether prodrugs from PRINT nanoparticles. J Am Chem Soc. 2012; 134(18):7978-82. PMC: 3362319. DOI: 10.1021/ja301710z. View

20.

Li F, Josephson D, Stein A . Colloidal assembly: the road from particles to colloidal molecules and crystals. Angew Chem Int Ed Engl. 2010; 50(2):360-88. DOI: 10.1002/anie.201001451. View