A Review on Electrospun Poly(amino Acid) Nanofibers and Their Applications of Hemostasis and Wound Healing

Overview

Journal Biomolecules

Publisher MDPI

Specialties Biochemistry
Molecular Biology

Date 2022 Jun 24

PMID 35740919

Authors

Yuexin Ji

Wenliang Song

Lin Xu

Deng-Guang Yu

Sim Wan Annie Bligh

Affiliations

Soon will be listed here.

Abstract

The timely and effective control and repair of wound bleeding is a key research issue all over the world. From traditional compression hemostasis to a variety of new hemostatic methods, people have a more comprehensive understanding of the hemostatic mechanism and the structure and function of different types of wound dressings. Electrospun nanofibers stand out with nano size, high specific surface area, higher porosity, and a variety of complex structures. They are high-quality materials that can effectively promote wound hemostasis and wound healing because they can imitate the structural characteristics of the skin extracellular matrix (ECM) and support cell adhesion and angiogenesis. At the same time, combined with amino acid polymers with good biocompatibility not only has high compatibility with the human body but can also be combined with a variety of drugs to further improve the effect of wound hemostatic dressing. This paper summarizes the application of different amino acid electrospun wound dressings, analyzes the characteristics of different materials in preparation and application, and looks forward to the development of directions of poly(amino acid) electrospun dressings in hemostasis.

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References

Gupta S, Mishra V, Mukherjee M, Saini P, Ranjan K . Amino acid derived biopolymers: Recent advances and biomedical applications. Int J Biol Macromol. 2021; 188:542-567. DOI: 10.1016/j.ijbiomac.2021.08.036. View

Habiba U, Afifi A, Salleh A, Ang B . Chitosan/(polyvinyl alcohol)/zeolite electrospun composite nanofibrous membrane for adsorption of Cr, Fe and Ni. J Hazard Mater. 2016; 322(Pt A):182-194. DOI: 10.1016/j.jhazmat.2016.06.028. View

Adelnia H, Tran H, Little P, Blakey I, Ta H . Poly(aspartic acid) in Biomedical Applications: From Polymerization, Modification, Properties, Degradation, and Biocompatibility to Applications. ACS Biomater Sci Eng. 2021; 7(6):2083-2105. DOI: 10.1021/acsbiomaterials.1c00150. View

Xu L, Liu Y, Zhou W, Yu D . Electrospun Medical Sutures for Wound Healing: A Review. Polymers (Basel). 2022; 14(9). PMC: 9105379. DOI: 10.3390/polym14091637. View

Mishra S, Chhatbar K, Kashikar A, Mehndiratta A . Diabetic foot. BMJ. 2017; 359:j5064. PMC: 5688746. DOI: 10.1136/bmj.j5064. View

Xu H, Zhang F, Wang M, Lv H, Yu D, Liu X . Electrospun hierarchical structural films for effective wound healing. Biomater Adv. 2022; 136:212795. DOI: 10.1016/j.bioadv.2022.212795. View

Wang W, Wu Z, Dai Z, Yang Y, Wang J, Wu G . Glycine metabolism in animals and humans: implications for nutrition and health. Amino Acids. 2013; 45(3):463-77. DOI: 10.1007/s00726-013-1493-1. View

Hussein Y, El-Fakharany E, Kamoun E, Loutfy S, Amin R, Taha T . Electrospun PVA/hyaluronic acid/L-arginine nanofibers for wound healing applications: Nanofibers optimization and in vitro bioevaluation. Int J Biol Macromol. 2020; 164:667-676. DOI: 10.1016/j.ijbiomac.2020.07.126. View

Guo S, Jiang W, Shen L, Zhang G, Gao Y, Yang Y . Electrospun Hybrid Films for Fast and Convenient Delivery of Active Herb Extracts. Membranes (Basel). 2022; 12(4). PMC: 9031211. DOI: 10.3390/membranes12040398. View

10.

Sandoval-Herrera I, Romero-Garcia J, Ledezma-Perez A, Alvarado-Canche C, Torres-Lubian R, De-Leon A . Controlled Release of Chlorogenic Acid from Polyvinyl Alcohol/Poly(γ-Glutamic Acid) Blended Electrospun Nanofiber Mats with Potential Applications in Diabetic Foot Treatment. Polymers (Basel). 2021; 13(17). PMC: 8434031. DOI: 10.3390/polym13172943. View

11.

Croitoru A, Ficai D, Ficai A, Mihailescu N, Andronescu E, Turculet C . Nanostructured Fibers Containing Natural or Synthetic Bioactive Compounds in Wound Dressing Applications. Materials (Basel). 2020; 13(10). PMC: 7287851. DOI: 10.3390/ma13102407. View

12.

Versteeg H, Heemskerk J, Levi M, Reitsma P . New fundamentals in hemostasis. Physiol Rev. 2013; 93(1):327-58. DOI: 10.1152/physrev.00016.2011. View

13.

Khan W, Muthupandian S, Farah S, Kumar N, Domb A . Biodegradable polymers derived from amino acids. Macromol Biosci. 2011; 11(12):1625-36. DOI: 10.1002/mabi.201100324. View

14.

Armstrong D, Boulton A, Bus S . Diabetic Foot Ulcers and Their Recurrence. N Engl J Med. 2017; 376(24):2367-2375. DOI: 10.1056/NEJMra1615439. View

15.

Srinath D, Lin S, Knight D, Rizkalla A, Mequanint K . Fibrous biodegradable l-alanine-based scaffolds for vascular tissue engineering. J Tissue Eng Regen Med. 2012; 8(7):578-88. DOI: 10.1002/term.1562. View

16.

Singh A, Maqsood Z, Iqubal M, Ali J, Baboota S . Compendium of Conventional and Targeted Drug Delivery Formulation Used for the Treatment and Management of the Wound Healing. Curr Drug Deliv. 2021; 19(2):192-211. DOI: 10.2174/1567201818666210727165916. View

17.

Liu Y, Chen X, Yu D, Liu H, Liu Y, Liu P . Electrospun PVP-Core/PHBV-Shell Fibers to Eliminate Tailing Off for an Improved Sustained Release of Curcumin. Mol Pharm. 2021; 18(11):4170-4178. DOI: 10.1021/acs.molpharmaceut.1c00559. View

18.

Zhao K, Kang S, Yang Y, Yu D . Electrospun Functional Nanofiber Membrane for Antibiotic Removal in Water: Review. Polymers (Basel). 2021; 13(2). PMC: 7827756. DOI: 10.3390/polym13020226. View

19.

Engelmann B, Massberg S . Thrombosis as an intravascular effector of innate immunity. Nat Rev Immunol. 2012; 13(1):34-45. DOI: 10.1038/nri3345. View

20.

Shen J, Zhou Z, Chen D, Wang Y, He Y, Wang D . Poly(aspartic acid) based self-healing hydrogels with antibacterial and light-emitting properties for wound repair. Colloids Surf B Biointerfaces. 2021; 200:111568. DOI: 10.1016/j.colsurfb.2021.111568. View