Adverse Outcome Pathways Mechanistically Describing Hepatotoxicity

Overview

Journal Methods Mol Biol

Specialty Molecular Biology

Date 2024 Sep 23

PMID 39312169

Authors

Ellen Callewaert

Jochem Louisse

Nynke Kramer

Julen Sanz-Serrano

Mathieu Vinken

Affiliations

Soon will be listed here.

Abstract

Adverse outcome pathways (AOPs) describe toxicological processes from a dynamic perspective by linking a molecular initiating event to a specific adverse outcome via a series of key events and key event relationships. In the field of computational toxicology, AOPs can potentially facilitate the design and development of in silico prediction models for hazard identification. Various AOPs have been introduced for several types of hepatotoxicity, such as steatosis, cholestasis, fibrosis, and liver cancer. This chapter provides an overview of AOPs on hepatotoxicity, including their development, assessment, and applications in toxicology.

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