Skin Carotenoids Are Related to Cognitive Abilities Among Toddlers

Overview

Journal J Nutr

Publisher Elsevier

Specialty Nutritional Sciences

Date 2024 Sep 15

PMID 39278413

Authors

Laura M Rosok

Lexi M Fifield

Rhea Sarma

Shelby A Keye

Anne M Walk

Naiman A Khan

Affiliations

Soon will be listed here.

Abstract

Background: Carotenoids are antioxidant pigments that deposit in human tissues (e.g., skin, macula, and brain) upon dietary consumption. The health implications of skin carotenoids, which reflect overall dietary carotenoid consumption, have not been adequately studied in younger populations.

Objectives: This work aimed to examine links between skin carotenoids and cognitive, language, and motor skills among toddlers. A secondary aim explored relationships between skin carotenoids and neurophysiologic outcomes of sensory memory [i.e., mismatch negativity (MMN)] and the functional integrity of the visual pathway [i.e., visual evoked potentials (VEPs)].

Methods: Toddlers aged 12-18 mo (n = 45) were included in a cross-sectional study. Skin carotenoids were measured with reflection spectroscopy via the Veggie Meter®. Cognitive, language, and motor skills were measured using the Bayley Scale of Infant and Toddler Development IV Screening Test (BSID-IV). MMN and VEPs were collected with an auditory oddball task and a pattern reversal task, respectively, using electroencephalography. Analyses adjusted for age, household income, highest level of parental education, and total carotenoid intake (mg/1000 kcal).

Results: Regression modeling revealed that skin carotenoids significantly related to cognition (β = 0.24; P = 0.04) and not to any other BSID-IV subsets. Neither MMN nor VEP outcomes significantly related to skin carotenoids.

Conclusions: Greater skin carotenoids were selectively related to cognition, indicating that carotenoids may play a role in cognition in toddlers. Additional research is needed to understand links between skin carotenoids and specific domains of cognitive function and brain health in early life.

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References

Cannavale C, Keye S, Rosok L, Martell S, Holthaus T, Reeser G . Enhancing children's cognitive function and achievement through carotenoid consumption: The Integrated Childhood Ocular Nutrition Study (iCONS) protocol. Contemp Clin Trials. 2022; 122:106964. PMC: 10150405. DOI: 10.1016/j.cct.2022.106964. View

Jilcott Pitts S, Johnson N, Wu Q, Firnhaber G, Preet Kaur A, Obasohan J . A meta-analysis of studies examining associations between resonance Raman spectroscopy-assessed skin carotenoids and plasma carotenoids among adults and children. Nutr Rev. 2021; 80(2):230-241. PMC: 8754254. DOI: 10.1093/nutrit/nuab016. View

Luck S, Gaspelin N . How to get statistically significant effects in any ERP experiment (and why you shouldn't). Psychophysiology. 2016; 54(1):146-157. PMC: 5178877. DOI: 10.1111/psyp.12639. View

Sun H, Li Q, Chen X, Tao L . Mismatch negativity, social cognition, and functional outcomes in patients after traumatic brain injury. Neural Regen Res. 2015; 10(4):618-23. PMC: 4424756. DOI: 10.4103/1673-5374.155437. View

Ermakov I, Gellermann W . Optical detection methods for carotenoids in human skin. Arch Biochem Biophys. 2015; 572:101-111. DOI: 10.1016/j.abb.2015.01.020. View

Vishwanathan R, Kuchan M, Sen S, Johnson E . Lutein and preterm infants with decreased concentrations of brain carotenoids. J Pediatr Gastroenterol Nutr. 2014; 59(5):659-65. DOI: 10.1097/MPG.0000000000000389. View

Faldella G, Govoni M, Alessandroni R, Marchiani E, Salvioli G, Biagi P . Visual evoked potentials and dietary long chain polyunsaturated fatty acids in preterm infants. Arch Dis Child Fetal Neonatal Ed. 1996; 75(2):F108-12. PMC: 1061173. DOI: 10.1136/fn.75.2.f108. View

Mewborn C, Lindbergh C, Robinson T, Gogniat M, Terry D, Jean K . Lutein and Zeaxanthin Are Positively Associated with Visual-Spatial Functioning in Older Adults: An fMRI Study. Nutrients. 2018; 10(4). PMC: 5946243. DOI: 10.3390/nu10040458. View

Winkler I, Czigler I . Evidence from auditory and visual event-related potential (ERP) studies of deviance detection (MMN and vMMN) linking predictive coding theories and perceptual object representations. Int J Psychophysiol. 2011; 83(2):132-43. DOI: 10.1016/j.ijpsycho.2011.10.001. View

10.

Darvin M, Lademann J, von Hagen J, Lohan S, Kolmar H, Meinke M . Carotenoids in Human SkinIn Vivo: Antioxidant and Photo-Protectant Role against External and Internal Stressors. Antioxidants (Basel). 2022; 11(8). PMC: 9394334. DOI: 10.3390/antiox11081451. View

11.

Fisher J, Butte N, Mendoza P, Wilson T, Hodges E, Reidy K . Overestimation of infant and toddler energy intake by 24-h recall compared with weighed food records. Am J Clin Nutr. 2008; 88(2):407-15. DOI: 10.1093/ajcn/88.2.407. View

12.

Hesterberg K, Lademann J, Patzelt A, Sterry W, Darvin M . Raman spectroscopic analysis of the increase of the carotenoid antioxidant concentration in human skin after a 1-week diet with ecological eggs. J Biomed Opt. 2009; 14(2):024039. DOI: 10.1117/1.3119257. View

13.

Meinke M, Darvin M, Vollert H, Lademann J . Bioavailability of natural carotenoids in human skin compared to blood. Eur J Pharm Biopharm. 2010; 76(2):269-74. DOI: 10.1016/j.ejpb.2010.06.004. View

14.

Saint S, Renzi-Hammond L, Khan N, Hillman C, Frick J, Hammond B . The Macular Carotenoids are Associated with Cognitive Function in Preadolescent Children. Nutrients. 2018; 10(2). PMC: 5852769. DOI: 10.3390/nu10020193. View

15.

Hasnin S, Dev D, Swindle T, Sisson S, Jilcott Pitts S, Purkait T . Systematic Review of Reflection Spectroscopy-Based Skin Carotenoid Assessment in Children. Nutrients. 2023; 15(6). PMC: 10055935. DOI: 10.3390/nu15061315. View

16.

Lindbergh C, Renzi-Hammond L, Hammond B, Terry D, Mewborn C, Puente A . Lutein and Zeaxanthin Influence Brain Function in Older Adults: A Randomized Controlled Trial. J Int Neuropsychol Soc. 2017; 24(1):77-90. DOI: 10.1017/S1355617717000534. View

17.

Tung K, Wilkens L, Wu A, McDuffie K, Hankin J, Nomura A . Association of dietary vitamin A, carotenoids, and other antioxidants with the risk of ovarian cancer. Cancer Epidemiol Biomarkers Prev. 2005; 14(3):669-76. DOI: 10.1158/1055-9965.EPI-04-0550. View

18.

Gale C, Hall N, Phillips D, Martyn C . Plasma antioxidant vitamins and carotenoids and age-related cataract. Ophthalmology. 2001; 108(11):1992-8. DOI: 10.1016/s0161-6420(01)00833-8. View

19.

Walk A, Khan N, Barnett S, Raine L, Kramer A, Cohen N . From neuro-pigments to neural efficiency: The relationship between retinal carotenoids and behavioral and neuroelectric indices of cognitive control in childhood. Int J Psychophysiol. 2017; 118():1-8. PMC: 5551452. DOI: 10.1016/j.ijpsycho.2017.05.005. View

20.

Brown M, Ferruzzi M, Nguyen M, Cooper D, Eldridge A, Schwartz S . Carotenoid bioavailability is higher from salads ingested with full-fat than with fat-reduced salad dressings as measured with electrochemical detection. Am J Clin Nutr. 2004; 80(2):396-403. DOI: 10.1093/ajcn/80.2.396. View