The Macular Carotenoids Are Associated with Cognitive Function in Preadolescent Children

Overview

Journal Nutrients

Date 2018 Feb 15

PMID 29439387

Citations 20

Authors

Sarah E Saint

Lisa M Renzi-Hammond

Naiman A Khan

Charles H Hillman

Janet E Frick

Billy R Hammond

Affiliations

Soon will be listed here.

Abstract

The macular carotenoids lutein (L) and zeaxanthin (Z) are obtained via diet and accumulate in the central retina where they are referred to as macular pigment. The density of this biomarker (macular pigment optical density; MPOD) has been positively correlated with cognitive functioning via measures of global cognition, processing speed, and visual-spatial abilities, among others. Although improvements in cognitive function have been found in adults, much less is known about how L and Z intake may support or improve cognitive functioning during periods of rapid developmental change, such as childhood and pre-adolescence. This study examined the relationship between MPOD and cognitive functioning in 51 7-13-year-old children (51% female). MPOD was measured using heterochromatic flicker photometry (HFP) optimized for this age group. Cognitive function was assessed using the Woodcock-Johnson III (composite standard scores were obtained for Brief Intellectual Ability, Verbal Ability, Cognitive Efficiency, Processing Speed, and Executive Processes). In this sample, MPOD was significantly related to Executive Processes, (47) = 0.288, < 0.05, and Brief Intellectual Ability, (47) = 0.268, < 0.05. The relationship to Cognitive Efficiency was positive and trending but not significant, (49) = 0.206, = 0.074. In general, these data are consistent with those of adults showing a link between higher carotenoid status and improved cognitive functioning.

Citing Articles

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References

McCorkle S, Raine L, Hammond B, Renzi-Hammond L, Hillman C, Khan N . Reliability of Heterochromatic Flicker Photometry in Measuring Macular Pigment Optical Density among Preadolescent Children. Foods. 2017; 4(4):594-604. PMC: 5224552. DOI: 10.3390/foods4040594. View

Walk A, Khan N, Barnett S, Raine L, Kramer A, Cohen N . From neuro-pigments to neural efficiency: The relationship between retinal carotenoids and behavioral and neuroelectric indices of cognitive control in childhood. Int J Psychophysiol. 2017; 118():1-8. PMC: 5551452. DOI: 10.1016/j.ijpsycho.2017.05.005. View

Hassevoort K, Khazoum S, Walker J, Barnett S, Raine L, Hammond B . Macular Carotenoids, Aerobic Fitness, and Central Adiposity Are Associated Differentially with Hippocampal-Dependent Relational Memory in Preadolescent Children. J Pediatr. 2017; 183:108-114.e1. DOI: 10.1016/j.jpeds.2017.01.016. View

Hammond Jr B . Possible role for dietary lutein and zeaxanthin in visual development. Nutr Rev. 2008; 66(12):695-702. DOI: 10.1111/j.1753-4887.2008.00121.x. View

Stahl W, Sies H . Effects of carotenoids and retinoids on gap junctional communication. Biofactors. 2002; 15(2-4):95-8. DOI: 10.1002/biof.5520150209. View

Rose S, Feldman J, Jankowski J, Van Rossem R . Basic Information Processing Abilities at 11 years Account for Deficits in IQ Associated with Preterm Birth. Intelligence. 2011; 39(4):198-209. PMC: 3106278. DOI: 10.1016/j.intell.2011.03.003. View

Rose S, Feldman J, Jankowski J . Implications of infant cognition for executive functions at age 11. Psychol Sci. 2012; 23(11):1345-55. DOI: 10.1177/0956797612444902. View

Johnson E . Role of lutein and zeaxanthin in visual and cognitive function throughout the lifespan. Nutr Rev. 2014; 72(9):605-12. DOI: 10.1111/nure.12133. View

Wooten B, Hammond Jr B, Land R, Snodderly D . A practical method for measuring macular pigment optical density. Invest Ophthalmol Vis Sci. 1999; 40(11):2481-9. View

10.

Renzi L, Hammond Jr B . The relation between the macular carotenoids, lutein and zeaxanthin, and temporal vision. Ophthalmic Physiol Opt. 2010; 30(4):351-7. DOI: 10.1111/j.1475-1313.2010.00720.x. View

11.

Johnson E, McDonald K, Caldarella S, Chung H, Troen A, Snodderly D . Cognitive findings of an exploratory trial of docosahexaenoic acid and lutein supplementation in older women. Nutr Neurosci. 2008; 11(2):75-83. DOI: 10.1179/147683008X301450. View

12.

Hammond Jr B, Wooten B . CFF thresholds: relation to macular pigment optical density. Ophthalmic Physiol Opt. 2005; 25(4):315-9. DOI: 10.1111/j.1475-1313.2005.00271.x. View

13.

Walk A, Edwards C, Baumgartner N, Chojnacki M, Covello A, Reeser G . The Role of Retinal Carotenoids and Age on Neuroelectric Indices of Attentional Control among Early to Middle-Aged Adults. Front Aging Neurosci. 2017; 9:183. PMC: 5465972. DOI: 10.3389/fnagi.2017.00183. View

14.

Barnett S, Khan N, Walk A, Raine L, Moulton C, Cohen N . Macular pigment optical density is positively associated with academic performance among preadolescent children. Nutr Neurosci. 2017; 21(9):632-640. PMC: 6251725. DOI: 10.1080/1028415X.2017.1329976. View

15.

Johnson E, Vishwanathan R, Johnson M, Hausman D, Davey A, Scott T . Relationship between Serum and Brain Carotenoids, α-Tocopherol, and Retinol Concentrations and Cognitive Performance in the Oldest Old from the Georgia Centenarian Study. J Aging Res. 2013; 2013:951786. PMC: 3690640. DOI: 10.1155/2013/951786. View

16.

Jia Y, Sun L, Yu H, Liang L, Li W, Ding H . The Pharmacological Effects of Lutein and Zeaxanthin on Visual Disorders and Cognition Diseases. Molecules. 2017; 22(4). PMC: 6154331. DOI: 10.3390/molecules22040610. View

17.

Feeney J, Finucane C, Savva G, Cronin H, Beatty S, Nolan J . Low macular pigment optical density is associated with lower cognitive performance in a large, population-based sample of older adults. Neurobiol Aging. 2013; 34(11):2449-56. DOI: 10.1016/j.neurobiolaging.2013.05.007. View

18.

Vishwanathan R, Kuchan M, Sen S, Johnson E . Lutein and preterm infants with decreased concentrations of brain carotenoids. J Pediatr Gastroenterol Nutr. 2014; 59(5):659-65. DOI: 10.1097/MPG.0000000000000389. View

19.

Ozawa Y, Sasaki M, Takahashi N, Kamoshita M, Miyake S, Tsubota K . Neuroprotective effects of lutein in the retina. Curr Pharm Des. 2012; 18(1):51-6. PMC: 3319923. DOI: 10.2174/138161212798919101. View

20.

Kelly D, Coen R, Akuffo K, Beatty S, Dennison J, Moran R . Cognitive Function and Its Relationship with Macular Pigment Optical Density and Serum Concentrations of its Constituent Carotenoids. J Alzheimers Dis. 2015; 48(1):261-77. PMC: 4923753. DOI: 10.3233/JAD-150199. View