The Paradox of Senescent-marker Positive Cancer Cells: Challenges and Opportunities

Overview

Journal NPJ Aging

Publisher Springer Nature

Specialty Geriatrics

Date 2024 Sep 14

PMID 39277623

Authors

Emily A OSullivan

Ryan Wallis

Federica Mossa

Cleo L Bishop

Affiliations

Soon will be listed here.

Abstract

Senescence is an anti-tumour mechanism and hallmark of cancer. Loss or mutation of key senescence effectors, such as p16INK4A, are frequently observed in cancer. Intriguingly, some human tumours are both proliferative and senescent-marker positive (Sen-Mark+). Here, we explore this paradox, focusing on the prognostic consequences and the current challenges in classifying these cells. We discuss future strategies for Sen-Mark+ cell detection together with emerging opportunities to exploit senescence for cancer.

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