Senescence Rewires Microenvironment Sensing to Facilitate Antitumor Immunity

Overview

Journal Cancer Discov

Specialty Oncology

Date 2022 Oct 27

PMID 36302222

Authors

Hsuan-An Chen

Yu-Jui Ho

Riccardo Mezzadra

Jose M Adrover

Ryan Smolkin

Changyu Zhu

Katharina Woess

Nicholas Bernstein

Georgia Schmitt

Linda Fong

Wei Luan

Alexandra Wuest

Sha Tian

Xiang Li

Caroline Broderick

Ronald C Hendrickson

Mikala Egeblad

Zhenghao Chen

Direna Alonso-Curbelo

Scott W Lowe

Affiliations

Soon will be listed here.

Abstract

Significance: Our work uncovers an interplay between tissue remodeling and tissue-sensing programs that can be engaged by senescence in advanced cancers to render tumor cells more visible to the adaptive immune system. This new facet of senescence establishes reciprocal heterotypic signaling interactions that can be induced therapeutically to enhance antitumor immunity. See related article by Marin et al., p. 410. This article is highlighted in the In This Issue feature, p. 247.

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